We found that RIG-I or MDA5 mutants with low ATP hydrolysis activity exhibit constitutive activity but this was fully reverted when associated with mutations preventing RNA binding to the …

2012年2月7日 · Structural insights explain how MDA5, critical for detecting viral infection in cells, senses and signals the presence of viral RNA. MDA5 forms filaments on long dsRNAs, …

RIG-I (Retinoic acid-inducible gene I) and MDA5 (Melanoma Differentiation-Associated protein 5), collectively known as the RIG-I-like receptors (RLRs), are key protein sensors of the pathogen …

MDA5 recognizes long duplex RNAs that presumably exist in a complex higher-order configuration, engaging RNA through interactions with its helicase (HEL) and carboxy-terminal …

MDA5 (melanoma differentiation-associated protein 5) is a RIG-I-like receptor dsRNA helicase enzyme that is encoded by the IFIH1 gene in humans. [5] MDA5 is part of the RIG-I-like …

2014年12月24日 · MDA5 binds long RNA duplex cooperatively and together they form helical fiber-like mega-structures through its RNA sensing module, the HEL-CTD (24, 26–27, 41–42). …

The aim of this study is to identify the domains in the MDA5 protein that are the target of autoantibodies, which could lead to more insight into the disease mechanism. Methods: The …

2019年1月1日 · MDA5 comprises two N terminal CARD domains, a central helicase domain, and a C terminal domain (CTD). Both the helicase domain and the CTD are involved in RNA …

MDA5 is another member of the RLR helicase family that functions as a cytosolic receptor for viral dsRNAs. MDA5 shares with RIG-I the same domain architecture and the downstream …

RIG-I (Retinoic acid-inducible gene I) and MDA5 (Melanoma Differentiation-Associated protein 5), collectively known as the RIG-I-like receptors (RLRs), are key protein sensors of the pathogen …