Utilizing nonobese diabetic (NOD) mice lacking Ifih1 expression (KO) or containing an in-frame deletion within the ATPase site of the helicase 1 domain of MDA5 (ΔHel1), we tested the …

在K63连接的泛素链的介导下，寡聚的RIG-I或MDA5通过其N端的caspase recruitment domain（CARD）与定位在线粒体膜上的MAVS（也被称为IPS-1、VISA或Cardif）发生相互 …

MDA5 (melanoma differentiation-associated protein 5) is a RIG-I-like receptor dsRNA helicase enzyme that is encoded by the IFIH1 gene in humans. [5] MDA5 is part of the RIG-I-like …

2015年1月15日 · Here, by reducing MDA5 gene expression we have uncovered a unique IFN-I signature in NOD mice that has led to the expansion of regulatory T cells at the site of …

2024年10月3日 · MDA5-dependent interferon production and inflammation following viral infection can trigger autoimmune b-cell killing. Here, we examine the consequences of T1D-protective …

2018年5月1日 · Since T1D is a chronic proinflammatory autoimmune disease involving MDA5, we hypothesized that aberrant MDA5 expression and signaling can contribute to diabetogenic …

2020年6月1日 · By utilizing mice that lack (NOD.Ifih1 KO) or contain a deletion within the helicase 1 domain of MDA5 (NOD.Ifih1 ΔHel1), we can test the hypothesis that reduced MDA5 …

2022年2月12日 · 黑色素瘤分化相关基因 5（melanoma differentiation associated gene 5，MDA5）。 近年来，对RIG-I、MDA5的功能研究很透彻，RIG-I、MDA5可分别识别短链、 …

2020年4月15日 · In this study, we report on the synergism and antagonism between NOD1 and MDA5 isoforms in teleost. In zebrafish, the overexpression of NOD1 enhances the antiviral …

2022年12月13日 · Utilizing nonobese diabetic (NOD) mice lacking Ifih1 expression (KO) or containing an in-frame deletion within the ATPase site of the helicase 1 domain of MDA5 (Δ …