Milk fat globule-EGF factor 8 protein (Mfge8), also known as lactadherin, is a protein that in humans is encoded by the MFGE8 gene. [5][6] Mfge8 is a secreted protein found in vertebrates, including mammals as well as birds. MFGE8 may function as a cell adhesion protein to connect smooth muscle to elastic fibers in arteries. [7] .

2024年12月25日 · MFGE8 (Milk Fat Globule EGF And Factor V/VIII Domain Containing) is a Protein Coding gene. Diseases associated with MFGE8 include Topographical Agnosia and Anal Paget's Disease.

2014年1月1日 · Milk Fat Globule-Epidermal Growth Factor-Factor 8 (MFG-E8) with bivalent binding activity to integrin receptors and acidic phospholipids is a secretary glycoprotein exhibiting versatile functions in cell physiology affecting health and diseases.

MFG-E8 is expressed and secreted by a variety of cells and tissues, especially professional and non-professional phagocytes such as macrophages, immature dendritic cells and the epithelial cells of mammary glands and epididy-mis.

MFG-E8 suppresses T cell activation/proliferation and inhibits Th1, Th2, and Th17 subpopulations while increasing regulatory T cell subsets. Neutralizing MFG-E8 substantially abrogates these effects, whereas addition of recombinant MFG-E8 to differentiated ESCs restores immunosuppression.

Milk fat globule epidermal growth factor 8 (MFG-E8) on monocytes is a novel biomarker of disease activity in systemic lupus erythematosus. Absence of the MFG-E8 gene prevents hypoxia-induced pulmonary hypertension in mice. The expression levels and clinical significance of MFG-E8 and CD133 in epithelial ovarian cancer.

We measured MFG-E8 production in the BV-2 microglial cell line and the role of this protein in the recognition and engulfment of apoptotic SY5Y neuroblastoma cells. BV-2 cells produced and released MFG-E8, which apoptotic SY5Y cells and the chemokine fractalkine further stimulated.

2004年3月19日 · Milk fat globule epidermal growth factor 8 (MFG-E8) (also known as lactadherin) is a secreted glycoprotein, and consists of two EGF-like domains, a mucin-like domain, and tandem discoidin-like...

2021年9月16日 · We focused on one of the main proteins detected in the Aβ-affected cerebrovasculature: MFG-E8 (milk fat globule-EGF factor 8), also known as lactadherin. We first validated the presence of MFG-E8 in mouse and human brains.

Traditionally, MFG-E8 was identified as an outstanding factor for phagocytosis of apoptotic cells and a significant factor in immune systems. Recent studies with some new findings have shed an interesting light on the old peripheral membrane glycoprotein in various diseases.