2019年11月26日 · MG132 treatment of MCF7-A24 cells resulted in significant increase in intracellular p53, but a decrease in surface A24, resulting in a net decrease in presentation of …

Proteasome inhibitors activate p53 and NF- ␬ B signaling pathway The effect of MG132 on p53 activation was examined. As shown in Fig. 4 A , increased expression of p53 was seen in …

The resulted showed that MG132 induced significant apoptosis, and caused the accumulation of p53 protein in both p53 wild-type and mutant-type thyroid cancer cell lines, whereas the …

2020年8月17日 · Liu et al. characterize a mechanism of UFL1-mediated UFMylation of p53 at multiple lysine residues and show how this dampens MDM2-induced ubiquitination of p53 to …

2012年5月15日 · MG132 INDUCES APOPTOSIS THROUGH P53-INDEPENDENT PATHWAY The tumor suppressor protein p53 is known to mediate apoptosis induced by the DNA tumor …

2024年11月19日 · In the presence of MG132, p53 levels were significantly stabilized in control cells (by approximately 20-fold compared with untreated cells) and also in Δ133p53α-WT …

Here we demonstrate that MG132, a proteasomal inhibitor, rapidly induces Noxa mRNA and protein in two human cell lines, T/C28a and Saos2. The induction of Noxa is associated with a …

2017年2月20日 · The resulted showed that MG132 induced significant apoptosis, and caused the accumulation of p53 protein in both p53 wild-type and mutant-type thyroid cancer cell lines, …

2012年2月28日 · MG132 markedly inhibited GBM cells growth irrespective of the p53 or PTEN mutational status of the cells whereas astrocytic viability was not affected, suggesting a …

6 天之前 · Ovarian cancer is the most lethal gynecological cancer, with a 5-year survival rate of approximately 50%. Mutation in the p53 gene and overexpression of the atypical protein …