cd1是一种类mhc-i家族糖蛋白，在序列、结构上与mhc-i十分相似：一条有三个结构域的α链和短小的β2m链，折叠成与mhc-i类似的结构。 按照氨基酸序列，CD1可以分为三组：CD1a、CD1b和CD1c为第一组，CD1d第二组，CD1e第三组。

This Review describes the journey taken by the MHC-class-I-like CD1 molecules, detailing their assembly, intracellular trafficking and loading with lipid antigens.

cd1（分化簇1）分为cd1a（r4），cd1b（r2），cd1c（r7），cd1d（r3）和cd1e（r2）五种。它们与mhcⅠ类分子的结构相似，可以提呈脂质或者糖脂质的抗原。另外，nkt细胞也只能接受由cd1d递呈的抗原。通常cd1分子在所有apc（抗原递呈细胞）和胸腺皮质细胞上都有表达。

CD1家族包括CD1a、CD1b、CD1c和CD1d，它们与抗原呈递和 T细胞免疫反应 密切相关：与经典的主要组织相容性复合物（ MHC ）相比，CD1蛋白在抗原呈递中具有独特的角色，特别是在 脂质抗原 引起的T细胞免疫反应中。 （数据来源 Moody DB, et al. Curr Opin Immunol. 2017） CD1a的 ...

2022年12月13日 · T cell-mediated targeting of tumor antigens presented by the monomorphic CD1 and MR1 molecules represents an alternative approach for adoptive cell therapies (ACT) via the generation of donor-unrestricted effector T cells that …

2015年9月21日 · New evidence shows that T cells recognizing CD1 or MR1 proteins are abundant in humans, supporting the use of lipid and small-molecule antigens as a new approach to therapy. In early work,...

The CD1 proteins are a family of non-polymorphic, MHC class I-related molecules that present lipid antigens to subsets of T lymphocytes with innate- or adaptive-like immune functions. Recent studies have provided new insight into the identity of ...

2003年1月1日 · Four human CD1 proteins — CD1A, CD1B, CD1C and CD1D — present lipid antigens by insertion of lipids into a groove in the proteins to form CD1–lipid complexes. These …

In this Review, we summarize the unique properties of CD1 antigen presentation, contrasting these with MHC II proteins, and we also consider the possible influence of MHC II and Ii expression on CD1 trafficking and function.

2023年10月12日 · Here, we solved lipidomes for the four human CD1 antigen-presenting molecules, providing a map of self-lipid display. Answering a basic question, the detection of >2,000 CD1-lipid complexes demonstrates broad presentation of …