抗原呈递 - 知乎 - 知乎专栏
cd1是一种类mhc-i家族糖蛋白，在序列、结构上与mhc-i十分相似：一条有三个结构域的α链和短小的β2m链，折叠成与mhc-i类似的结构。 按照氨基酸序列，CD1可以分为三组：CD1a、CD1b …
CD1 antigen presentation: how it works - Nature
This Review describes the journey taken by the MHC-class-I-like CD1 molecules, detailing their assembly, intracellular trafficking and loading with lipid antigens.
cd1 - 百度百科
cd1（分化簇1）分为cd1a（r4），cd1b（r2），cd1c（r7），cd1d（r3）和cd1e（r2）五种。它们与mhcⅠ类分子的结构相似，可以提呈脂质或者糖脂质的抗原。另外，nkt细胞也只能接受 …
脂质抗原呈递分子CD1a - 知乎 - 知乎专栏
CD1家族包括CD1a、CD1b、CD1c和CD1d，它们与抗原呈递和 T细胞免疫反应 密切相关：与经典的主要组织相容性复合物（ MHC ）相比，CD1蛋白在抗原呈递中具有独特的角色，特别是在 …
CD1 and MR1: An update after a long-awaited reunion - Cell Press
2022年12月13日 · T cell-mediated targeting of tumor antigens presented by the monomorphic CD1 and MR1 molecules represents an alternative approach for adoptive cell therapies (ACT) …
Lipid and small-molecule display by CD1 and MR1 - Nature
2015年9月21日 · New evidence shows that T cells recognizing CD1 or MR1 proteins are abundant in humans, supporting the use of lipid and small-molecule antigens as a new …
Mechanisms and Consequences of Antigen Presentation by CD1
The CD1 proteins are a family of non-polymorphic, MHC class I-related molecules that present lipid antigens to subsets of T lymphocytes with innate- or adaptive-like immune functions. …
Intracellular pathways of CD1 antigen presentation - Nature
2003年1月1日 · Four human CD1 proteins — CD1A, CD1B, CD1C and CD1D — present lipid antigens by insertion of lipids into a groove in the proteins to form CD1–lipid complexes. These …
CD1 and MHC II find different means to the same end - Cell Press
In this Review, we summarize the unique properties of CD1 antigen presentation, contrasting these with MHC II proteins, and we also consider the possible influence of MHC II and Ii …
CD1 lipidomes reveal lipid-binding motifs and size-based antigen ...
2023年10月12日 · Here, we solved lipidomes for the four human CD1 antigen-presenting molecules, providing a map of self-lipid display. Answering a basic question, the detection of …