MHC class I molecules are heterodimers that consist of two polypeptide chains, α and β 2 -microglobulin (B2M). The two chains are linked noncovalently via interaction of B2M and the α 3 domain. Only the α chain is polymorphic and encoded by a HLA gene, while the B2M subunit is not polymorphic and encoded by the beta-2 microglobulin gene.

2022年9月26日 · Major histocompatibility complex (MHC) class I is a diverse set of cell surface receptors expressed on all nucleated cells in the body and platelets. MHC is also known as human leukocyte antigen (HLA), of which there are 3 subtypes: HLA-A, HLA-B, and HLA-C.

2011年11月11日 · This study explains the effects of IL-10 on MHC class II expression in human monocytes. IL-10 controls MARCH1 expression, which in turn controls the half-life of MHC class II on the cell...

One mechanism by which tumor cells can avoid immunosurveillance is through the downregulation of Major Histocompatibility Complex I (MHC-I). Downregulation of MHC-I has been described as a mechanism of intrinsic and acquired resistance to immunotherapy in …

The MHC class I antigen presentation system is constructed in such a way that most cells exclusively present their own antigens. Because of this, it was thought that CD8+ T cells selectively eliminate infected cells without destroying neighbouring ‘innocent bystanders’.

2022年6月10日 · MHC class I proteins are encoded by the HLA-A, HLA-B, and HLA-C genes encoding HLA-A, HLA-B, and HLA-C molecules respectively. Class I molecules are found on virtually all nucleated cells in the body including platelets. Key exceptions are observed on cells in the retina and brain and the non- nucleated red blood cells.

The most striking feature of MHC class Ib molecules is their highly conserved nature. Whereas MHC class Ia genes display extensive polymorphism among their family members, the prototypic mouse MHC class Ib Qa-1 and its direct human homolog HLA-E are essentially non-polymorphic. In this review we will refer to Qa-1 and HLA-E molecules as Qa-1/HLA-E.

2 天之前 · MHC class I and MHC class II influence susceptibility to autoimmune diseases and immune responses against infections. Variations in MHC gene expression and peptide-binding specificity determine how the immune system distinguishes between self and non-self, sometimes leading to unintended immune activation or immune evasion by pathogens.

2025年1月9日 · Explore the distinct structures, functions, and immune roles of MHC Class I and II molecules in antigen processing and cellular expression. The major histocompatibility complex (MHC) is essential in the immune system by presenting antigens to T cells, which is vital for immune recognition and response.

Thus, MHC class I helps mediate cellular immunity, a primary means to address intracellular pathogens, such as viruses and some bacteria, including bacterial L forms, bacterial genus Mycoplasma, and bacterial genus Rickettsia. In humans, MHC class I comprises HLA-A, HLA-B, and HLA-C molecules. [citation needed]