The NetMHCcons 1.1 server predicts binding of peptides to any known MHC class I molecule. This is a consensus method for MHC class I predictions integrating three state-of-the-art methods NetMHC, NetMHCpan and PickPocket to give the most accurate predictions.

MHC-Typer V1.1 Assigning alleles in multilocus amplification. Requirements: Windows platform, and .net framework 2.0 runtime library. New Features: V1.1: Considering CNV, heterozygote excess, sharing of identical alleles between loci. V1.1 For Windows, example files, user manual and 64bit executable:

A key role in cell-mediated immunity is dedicated to the major histocompatibility complex (MHC) molecules that bind peptides for presentation on the cell surface. Several in silico methods capable of predicting peptide binding to MHC class I have been developed. The accuracy of these methods depends …

We found that NetMHCcons v1.1 selected for epitopes that were immunogenic: 46% of the epitopes with <500nM binding affinity were immunogenic (Figure 2D, E), and 100% of the high-affinity epitopes generated either CD8 + or CD8 + /CD4 + T-cell responses (Fig. 2E).

2006年8月31日 · Here we describe in-depth procedures for the high-throughput production of peptide-MHC (pMHC) complexes by MHC exchange, the analysis of peptide exchange efficiency by ELISA and the parallel...

MHC分子是主要组织相容性复合物（Major Histocompatibility Complex）的缩写，在人类中也称为人类白细胞抗原（Human Leukocyte Antigen， HLA）。 这些分子在细胞表面上存在，并且可以识别并结合来自外界的抗原。 当抗原结合到MHC分子上时，就形成了一种复合物，被称为MHC-抗原复合物。 这种复合物可以被特定的T细胞所识别，从而激活免疫反应。 MHC分子有两种类型： MHC-I 和 MHC-II。 MHC-I分子广泛存在于各种细胞表面上，包括所有核细胞和一些质膜细胞。 …

2023年11月24日 · 主要组织相容性复合体（MHC）分子（人类中的组织相容性抗原 [HLA]分子）将短肽呈现在细胞表面，供T细胞识别，这是免疫疗法的核心。 由于高度多态性，每个个体的MHC可以结合一组独特的短肽。

什么是 MHC II？ MHC II 类分子由称为 抗原呈递细胞 (APC) 的特殊类型细胞表达。 APC 包括巨噬细胞、 B 细胞 和 树突状细胞。 当 MHC II 类分子遇到抗原时，它将抗原吸收到细胞中，对其进行处理，然后抗原分子的一部分（表位）呈现在 MHC II 类的表面上。

The NetCTL 1.2 server predicts CTL epitopes in protein sequences. The current version 1.2 is an update to the version 1.0. Version 1.2 expands the MHC class I binding predicition to 12 MHC supertypes including the supertypes A26 and B39. The accuracy of the MHC class I peptide binding affinity is significantly improved compared to the earlier ...

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