MK-0677, a spiroindoline sulfonamide, is a novel, orally active GH secretagogue. The effects of MK-0677 on serum GH and other hormones after oral and iv single dose administrations in beagles were evaluated. After oral administration in a balanced eight-dog crossover study, treatment with MK-0677 si …

Ibutamoren (INN; developmental code MK-677, MK-0677, LUM-201, L-163,191; former tentative brand name Oratrope) is a potent, long-acting, orally-active, selective, and non-peptide agonist of the ghrelin receptor and a growth hormone secretagogue, mimicking the growth hormone (GH)-stimulating action of the endogenous hormone ghrelin. [3][4][5][6][...

2018年3月1日 · MK-0677, an oral ghrelin receptor agonist (GRA), maintains normal GH secretion and increases lean body mass in normal subjects; it has not been studied in dialysis patients, an essential step in assessing efficacy and safety prior to clinical trials.

mk-0677 给药后的 gh 曲线包括高于对照的间歇性增加 。 MK-0677 在口服后显著增加峰值 GH 浓度。 MK-0677 是一种有效的 GH 促分泌剂，口服或静脉注射时可立即、大幅度、持久地增加 GH 水平 [4] 。

Objectives: To evaluate the effects of MK-0677, an orally active growth hormone (GH) secretagogue, on functional recovery from hip fracture in previously mobile older individuals. Design: Placebo-controlled, randomized, double-blind trial.

MK-0677, which is also known as ibutamoren mesylate or L-163,191, is a non-peptide ghrelin agonist with higher efficacy compared to ghrelin when it is bound to GHS-R1a [40,41,42]. The half-life of MK-0677 is 6 h, which is approximately 12 times longer than ghrelin’s 30 min [43,44].

产品介绍：Ibutamoren Mesylate (MK-677) 是一种有效的，非肽段类生长激素促分泌素受体 (GHSR) 激动剂。 Ibutamoren Mesylate 是一种有效的，具有口服活性的生长激素 (GH) 促分泌素。

MK 0677 is a high affinity ghrelin receptor agonist (pK i = 8.14). Growth hormone (GH) secretagog; stimulates GH release from rat pituitary cells in vitro (EC 50 = 1.3 nM) and enhances GH plasma levels in vivo .

This is a randomized, double-blind study of 123 elderly hip fracture patients assigned to receive 25mg/day of MK-0677 … Most elderly patients admitted for hip fracture suffer functional decline. Previous studies with MK-0677 in hip fracture patients …

2011年9月1日 · MK-0677 is a potent, orally available non-peptidyl GH-secretagogue mimetic, which binds to the ghrelin receptor and stimulates the secretion of GH (Chapman et al., 1996). Although inconclusive, a previous study of MK-0677 in patients recovering from a hip fracture, suggested that there was an improvement in muscle strength and in a number of ...