MK-886 (L 663536) is a potent, cell-permeable and orally active FLAP (IC 50 of 30 nM) and leukotriene biosynthesis (IC 50 s of 3 nM and 1.1 μM in intact leukocytes and human whole …

MK-886, or L-663536, is a leukotriene antagonist. It may perform this by blocking the 5-lipoxygenase activating protein (FLAP), thus inhibiting 5-lipoxygenase (5-LOX), [ 1 ] and may …

MK-886 (L 663536) sodium salt is a potent, cell-permeable and orally active FLAP (IC50 of 30 nM) and leukotriene biosynthesis (IC50 s of 3 nM and 1.1 μM in intact leukocytes and human …

2009年4月17日 · MK-886, an inhibitor of the 5-lipoxygenase-activating protein (FLAP), potently suppresses leukotriene biosynthesis in intact cells and is frequently used to define a role of the …

mk-886是一种白三烯生物合成的抑制剂，能够抑制5-脂氧合酶激活蛋白（flap）。 此外，MK-886还是PPARα的拮抗剂。 帮助客户创造价值，让世界更健康更快乐！

MK-886 (L 663536) is a potent, cell-permeable and orally active FLAP (IC 50 of 30 nM) and leukotriene biosynthesis (IC 50 s of 3 nM and 1.1 μM in intact leukocytes and human whole …

MK 886 is a potent inhibitor of 5-lipoxygenase-activating protein (FLAP) (IC 50 = 30 nM for inhibition of [125 I]-L-691,678 photoaffinity labelling). Inhibits leukotriene biosynthesis (IC 50 = …

MK-886: 一种FLAP抑制剂、PPARα抑制剂药物，由Merck Sharp & Dohme Corp. (Merck Sharp & Dohme Corp.)公司最早进行研发，目前全球最高研发状态为临床前，作用机制: FLAP抑制剂(5- …

MK 886 is a potent, cell-permeable and orally-active inhibitor of 5-lipoxygenase-activating protein (FLAP), with an IC50 value of 30 nM for inhibition of [125I]-L-691,678 photoaffinity labelling. …

A cell-permeable, orally active NSAID that blocks cellular Cox pathway PGE2 production by inhibiting COX-1 and mPGES-1, but not COX-2, activity, as well as suppresses cellular 5-LO …

In this study, we investigated proteasomal activation by MK886 (MK). We previously identified MK as a lead compound capable of modulating tau oligomerization in a cellular FRET assay and …

2021年11月4日 · Catalyzes the oxygenation of arachidonate ( (5Z,8Z,11Z,14Z)-eicosatetraenoate) to 5-hydroperoxyeicosatetraenoate (5-HPETE) followed by the dehydration …

MK 886 is a potent, cell-permeable and orally-active inhibitor of 5-lipoxygenase-activating protein (FLAP), with an IC50 value of 30 nM for inhibition of [125I]-L-691,678 photoaffinity labelling. …

Our results indicated that MK-886 treatment significantly attenuated I/R-mediated cardiac contractile dysfunction and decreased the infarct area, myocyte apoptosis, and oxidative …

2009年4月17日 · MK-886, an inhibitor of the 5-lipoxygenase-activating protein (FLAP), potently suppresses leukotriene biosynthesis in intact cells and is frequently used to define a role of the …

1990年1月25日 · In this report, we show that MK886 can both prevent and reverse the membrane translocation of 5-lipoxygenase, in conjunction with the inhibition of leukotriene synthesis.

1998年1月1日 · MK-886, a specific inhibitor of 5-lipoxygenase inhibited DNA replication in leukemic HL-60 cells in a dose-dependent manner. Addition of exogenous leukotriene B 4 …

MK-886, a leukotriene biosynthesis inhibitor, was evaluated in double-blind, placebo-controlled, randomized single- and multiple-dose studies in 12 and 24 healthy male subjects, respectively. …

Zheng N, Zhang Z, Liu H, Zong S, Zhang L, Cui X, Liu Y, Wang C, Chen R, Lu Z.MK886 ameliorates Alzheimer's disease by activating the PRKCI/AKT signaling pathway.

MK-886 (20 mg/kg) was administered intraperitoneally into mice at 1 and 24 h before I/R. Our results indicated that MK-886 treatment significantly attenuated I/R-mediated cardiac …