May 11, 2017 · Alpha-7 nicotinic acetylcholine receptor (α7-nAChR) agonists can prevent glutamate-induced excitotoxicity in cultured retinal ganglion cells (RGCs). However, the neuroprotective effects and the...

Apr 13, 2023 · We expect that methyllycaconitine (MLA) will inhibit the effect of PNU-282987 in blast-exposed mouse retinas. The hypothesis of this experiment is that PNU-282987 will act on the alpha 7 subtype of neural nicotinic acetylcholine receptors to induce neurogenesis.

May 11, 2021 · The changes in cognitive dysfunction were alleviated by PNU-282987; furthermore, MLA pretreatment offset the effect. In hippocampal tissues, TUNEL assays showed decreased apoptotic cells, immunohistochemical staining showed increased expressions of p-CREB and BDNF.

Sep 1, 2024 · In vitro experiments with MLA, PNU, BMS, and PNU + BMS on HKFs provided crucial insights into the potential synergistic effects of these compounds. Notably, the PNU + BMS combination exhibited superior efficacy in impairing cell migration, modulating key fibrotic markers, and influencing apoptosis-related proteins.

May 1, 2021 · Results: Compared to the CIH2W and RA groups, the CIH4W group showed cognitive dysfunction in the NOR and MWM tests. The changes in cognitive dysfunction were alleviated by PNU-282987;...

For PNU-282987 and methyllycaconitine (MLA) treatments (Sigma-Aldrich, St. Louis, MO, USA), RPE-J cells were grown to 70% to 80% confluence at 33°C and treated with normal culture media containing PNU-282987 (100 nM) for 24 hours, or MLA (1 μM) for 8 hours, followed by 100 nM PNU-282987 for 24 hours.

May 11, 2021 · Compared to those in the CIH (−0.141±0.125), sham (−0.082±0.161), and the MLA+PNU (−0.183±0.295) groups, the discrimination index of the PNU group (0.180±0.105) was significantly increased (Figure 2B), suggesting that PNU could improve the …

MLA (Modern Language Association) style is most commonly used to write papers and cite sources within the liberal arts and humanities. This resource, updated to reflect the MLA Handbook (9th ed.), offers examples for the general format of MLA research papers, in-text citations, endnotes/footnotes, and the Works Cited page.

Jun 23, 2022 · Results: Our results indicated that the PNU-282987 reduced inflammatory factors (MCP-1, IL-1β, MMP-9, TNF-α, HMGB1, TLR2), promoted the polarization of macrophage/microglia into anti-inflammatory subtypes (CD206), repaired blood-brain barrier injury (ZO-1, Claudin-5, Occludin), alleviated acute brain …

PNU-120596是α7烟碱乙酰胆碱受体（α7nAChR）的经典正变构调节剂（PAM），广泛用于研究α7nAChR活化对多种炎症相关疾病（包括类风湿性关节炎，炎症性肠病和脑缺血）的影响。