2021年4月7日 · Errors are targeted, excised, resynthesized and ligated (Cell Res 2008;18:85, The British Association of Gynaecological Pathologists: BAGP MMR IHC Interpretation June 2020 …

Clinically, the integrity of MMR is frequently assessed using immunohistochemical (IHC) staining for expression of the four MMR proteins, with loss of MLH1/PMS2 and/or MSH2/MSH6 …

2022年8月31日 · We describe a case of false loss of MMR IHC in a patient with metastatic CRC, caused by IHC interference because of a rare benign germline polymorphism in MLH1 with …

2020年1月1日 · Immunohistochemistry (IHC) for DNA mismatch repair proteins MLH1, PMS2, MSH2, and MSH6 is used for microsatellite instability (MSI) screening in colorectal carcinoma …

Immunohistochemistry (IHC) for mismatch repair (MMR) proteins is used to identify MMR status: being diffusely positive (intact/retained nuclear staining) or showing loss of nuclear tumour …

Loss of MLH-1 expression—usually accompanied by loss of PMS-2 expression—within tumours is the most commonly encountered abnormality on MMR protein IHC. This can indicate the …

MLH1基因 启动子区甲基化是 结直肠癌 （CRC）和 子宫内膜癌 （EC）常见的表观遗传改变，甲基化导致基因沉默，从而导致微卫星不稳定（MSI-H）。 通常，MLH1高度甲基化被认为是癌 …

2023年6月17日 · LS的普查方法包括MMR免疫组化 (IHC)，主要检测MLH1,MSH2,MSH6,PMS2四种蛋白的表达情况；以及微卫星不稳定性 (MSI)检测两种。 更进一步应结合BRAF V600E突变 …

Mismatch Repair Protein (MLH1) is recommended for the detection of specific antigens of interest in normal and neoplastic tissue, as an adjunct to conventional histopathology using non …

Purpose: Mismatch repair (MMR) immunohistochemistry (IHC) is frequently used to inform prognosis, select (immuno-)therapy, and identify patients for heritable cancer syndrome …