2024年11月8日 · Starting from a single MLH1- knockout human colon cell, we modeled the transition of daughter cells and resultant organoids from normal epithelium to carcinoma by …

2024年5月13日 · CT26 Mlh1 KO was sensitive to pan-caspase inhibitor Emricasan, caspase-8 inhibitor Z-IETD-FMK, and RIPK1 inhibitor Nec-1, all of which could inhibit cell death induced …

2020年2月26日 · Mlh1 knockout (MLH1-KO) cells have increased mutational burden, augmented number of predicted neoantigens, and higher immunogenicity . Because we previously found …

2021年1月11日 · In this study, we discovered a hitherto unknown MMR mechanism that modulates genome stability and has implications for cancer therapy. DNA mismatch repair …

While Brca2 L2431P/L2431P MEFs showed basal level of R-loops on Mlh1 +/+ and Mlh1 KO/+ genetic backgrounds, significant increases in R-loops were observed upon Mlh1 loss (Brca2 …

2025年1月17日 · 为了在体外解码其背后的基因突变机理，研究人员选择了类器官模型mlh1 ko 。 此模型通过敲除（KO）MLH1基因，可于 体外 短期培养 中重现d-MMR型CRC突变特征。

2020年7月9日 · Consistently, HORMAD1 KO elevated chromatin binding of MLH1, but not MSH2, in MDAH2774, A549, and HCC38 cells (Figs. 4g, S5C–D). Therefore, HORMAD1 expression …

本研究探讨了 PIK3CA 状态是否以及如何影响 COX-2 介导的肿瘤炎症和 dMMR CRC 的免疫治疗反应。 使用小鼠结肠癌细胞MC38、CT26和CT26- Mlh1- KO构建PIK3CA敲低和过表达模型 …

2025年1月15日 · In the control cultures (MLH1-KO and MLH1-KO—Empty vector), there was a gradual takeover of MLH1-KO cells, constituting 85% and 90% of the population, respectively …

通过敲除Mlh1基因exon 6，建立Mlh1基因敲除小鼠模型。 *使用本品系发表的文献需注明: Mlh1-KO (2) mice (Cat. NO. NM-KO-232962) were purchased from Shanghai Model Organisms …