The KMT2A/MLL consensus gene structure: a comprehensive …
2024年4月27日 · ENSEMBL lists exon 2 only in two full-length transcripts of KMT2A (ENST00000531904 and ENST00000649666). In addition to the discrepancies concerning …
Exon scrambling of MLL transcripts occur commonly and mimic …
1998年2月22日 · Using a sensitive reverse transcriptase-polymerase chain reaction (RT-PCR) assay, we identified several abnormally spliced transcripts in which MLL exons were joined in …
The reciprocal world of MLL fusions: A personal view
2020年7月1日 · The MLL gene exhibits 37 exons with a full coding potential of 4005 amino acids. Be aware that exon 2, coding for 33 amino acids, is not presented in the NCBI database gene …
Partial tandem duplication of KMT2A (MLL) may predict a subset …
Partial tandem duplication (PTD) of the KMT2A (MLL) gene is detected in approximately 5-10% of cases of acute myeloid leukemia (AML) 1–5 and within cases showing normal karyotype, …
MLL Gene Alterations in Acute Myeloid Leukaemia (11q23/MLL+ …
2011年11月13日 · Sequence of MLL PTD from sequencing, showing a break in exon8/exon2 (exon3/exon11). Previous studies have associated an MLL gene PTD with AML subtypes M1 …
Rare MLL-ELL fusion transcripts in childhood acute myeloid …
2016年3月5日 · In the majority of MLL-ELL fusion transcripts, exon 9, 10, 11 or 12 of MLL is fused to exon 2 of ELL [3, 8–13]. A variant form of MLL-ELL fusion transcript has been reported in …
Human MLL/KMT2A gene exhibits a second breakpoint cluster …
2019年3月21日 · In diagnostic fluorescence in situ hybridization analyses, these MLL–USP2 cases revealed two major patterns: (1) loss of the 3′-MLL probe signal, and (2) a normal …
DNA fragility at the KMT2A/MLL locus: insights from old and new ...
MLL translocation junction break sites (der-11) found in individual acute leukaemia (AL) cases fall within an 8.3 kb breakpoint cluster region (BCR), spanning intron 8 to exon 12 of the MLL …
MLL2 靶向基因座的全球鉴定揭示了 MLL2 在多种信号通路中的作 …
对 MLL2 野生型与 MLL2 缺失等基因细胞系中 MLL2 结合谱和基因表达的组合分析确定了直接转录靶基因，并揭示了 MLL2 与多种细胞信号通路的联系，包括 p53 通路、cAMP 介导的信号通 …
Reemergence of translocation t(11;19)(q23;p13.1) in the ... - Springer
2017年7月1日 · We report the case of a 10-year-old female with acute myeloid leukemia (AML) FAB M0 carrying a novel t (11;19) (q23;p13.1) MLL – ELL variant, in which intron 8 of MLL is …