Major League Lacrosse (MLL), the premier professional outdoor lacrosse league, was founded by Jake Steinfeld and is headquartered in Boston. MLL has continued to lead the...

Major League Lacrosse (MLL) was a men's field lacrosse league in the United States. The league's inaugural season was in 2001. [1] . Teams played anywhere from ten to 16 games in a summertime regular season. This was followed by a four-team playoff for the championship trophy, the Steinfeld Trophy, named after founder Jake Steinfeld.

The mixed-lineage leukemia 1 (MLL1) gene (now renamed Lysine [K]-specific MethylTransferase 2A or KMT2A) on chromosome 11q23 is disrupted in a unique group of acute leukemias.

LOS ANGELES (December 16, 2020) – The Premier Lacrosse League (“PLL”) and Major League Lacrosse (“MLL”) have merged with subsequent season operations and activities to formally exist under the Premier Lacrosse League.

The MLL–PLL merger represented a unification of the two major professional field lacrosse leagues in the United States at the time: Major League Lacrosse (MLL) and the Premier Lacrosse League (PLL). Initial terms of the merger were released on the morning of December 16, 2020.

2024年9月19日 · No, Major League Lacrosse (MLL) ceased to exist as an independent entity in December 2020. MLL merged with the Premier Lacrosse League (PLL) to unify professional field lacrosse. The Boston Cannons were rebranded as Cannons Lacrosse Club; the PLL gained rights to MLL’s remaining five teams for future expansion considerations.

2020年12月16日 · LOS ANGELES (AP) — The Premier Lacrosse League and Major League Lacrosse are merging and will formally exist as the Premier Lacrosse League. It’s another step …

MLL基因（myeloid/lymphoid leukemia或mixed lineage leukemia）也称为 ALL1 （acute lymphocytic leukemia 1）或HRX（homolog of trithorax），具有三个区域与果蝇三胸蛋白同源。 累及 MLL 基因的白血病既可见于ALL，也可见于AML。 见于AML的MLL异常，除MLL-PTD主要见于M1和M2外，其他的MLL融合基因大多见于M4和M5。 MLL蛋白包括氨基端的AT吊钩、SNL1和SNL2基序以及CxxC结构域，这些结构域通常保留在融合蛋白中。 其中AT吊钩可以特异结 …

混合谱系白血病（mixed lineage leukemia， MLL）基因重排（MLL -rearranged，MLL-r）引起的急性白血病亚型侵袭性高且预后不良，缺少特异性治疗手段。 MLL蛋白具有组蛋白甲基转移酶活性，在胚胎发育和正常造血中必不可少，可通过功能结构域与多种蛋白质相互作用，形成大分子复合体，并通过表观修饰调节下游靶基因的表达。 MLL-r转录形成MLL融合蛋白（MLL...

MLL白血病的特征是混合血统白血病 (MLL) 基因的染色体易位，从而与伴侣蛋白形成融合蛋白。 许多这些 MLL 融合伴侣蛋白都属于参与调节转录延伸的超级延伸复合物。 MLL 融合可产生致癌转录因子，导致癌基因或肿瘤抑制基因转录调节异常，从而启动肿瘤发生。 MLL1 被加工为两种多肽，这两种多肽均为野生型 MLL 复合物的亚基。 MLL1 的氨基末端包含在导致白血病发生的融合蛋白中。 我们建议使用羧基末端特异性抗体检测野生型 MLL1，使用氨基末端特异性抗体检测 …