2016年5月17日 · Mixed lineage leukemia protein-1 (MLL1) has a critical role in human MLL1 rearranged leukemia (MLLr) and is a validated therapeutic target. However, its role in...

The mixed-lineage leukemia 1 (MLL1) gene (now renamed Lysine [K]-specific MethylTransferase 2A or KMT2A) on chromosome 11q23 is disrupted in a unique group of acute leukemias. More than 80 different partner genes in these fusions have been ...

mll家族蛋白（mll1/2/3/4，set1a/b）是一类特异性针对h3k4的甲基转移酶，其甲基转移酶活性依赖于c末端的一个保守的set结构域。 前人实验发现，MLL家族蛋白与其他具有SET结构域的甲基转移酶不同，它行使功能需要多个辅助蛋白WDR5、RBBP5、ASH2L组成复合体才能有效完成 ...

2019年9月27日 · 经生化实验表明，富集赖氨酸的ctd3能高度亲和核小体dna，增强mll1复合物与核小体的相互作用，继而促进复合物酶活的高效发挥。 若将这些赖氨酸全部突变为丙氨酸，会削弱MLL1复合物结合核小体的能力，对其酶活发挥产生负调控。

2024年3月30日 · Infant and adult MLL1/KMT2A -rearranged (MLLr) leukemia represents a disease with a dismal prognosis. Here, we present a functional and proteomic characterization of in utero -initiated and...

混合谱系白血病（mixed lineage leukemia， MLL）基因重排（MLL -rearranged，MLL-r）引起的急性白血病亚型侵袭性高且预后不良，缺少特异性治疗手段。 MLL蛋白具有组蛋白甲基转移酶活性，在胚胎发育和正常造血中必不可少，可通过功能结构域与多种蛋白质相互作用，形成大分子复合体，并通过表观修饰调节下游靶基因的表达。 MLL-r转录形成MLL融合蛋白（MLL...

Mixed lineage leukemia protein-1 (MLL1) has a critical role in human MLL1 rearranged leukemia (MLLr) and is a validated therapeutic target. However, its role in...

Menin 是一种接头蛋白和抑癌基因，由多发性内分泌肿瘤 1 (MEN1) 基因编码。Menin 还与 MLL1 的羧基末端相互作用，并作为 MLL1 和 MLL 融合蛋白的关键辅助因子发挥作用。

2016年5月17日 · Mixed lineage leukemia protein-1 (MLL1) has a critical role in human MLL1 rearranged leukemia (MLLr) and is a validated therapeutic target. However, its role in regulating global gene expression in MLLr cells, as well as its interplay with …

2016年5月17日 · Mixed lineage leukemia protein-1 (MLL1) has a critical role in human MLL1 rearranged leukemia (MLLr) and is a validated therapeutic target. However, its role in regulating global gene expression in MLLr cells, as well as its interplay with …