2018年10月15日 · TIMP-1 and MMP-9 compose an extracellularly operating enzymatic system active locally around excitatory synapses to modulate their morphology, molecular content and efficacy. Animal studies have implicated MMP-9 in a variety of neuropsychiatric conditions, e.g., epileptogenesis, autism spectrum disorders, development of addiction, and depression.

2017年12月5日 · Further, the levels of MMP-3, MMP-13, ADAMTS-5 and IL-1β mRNAs were significantly increased by IL-1β treatment and significantly decreased by T-5224 in a dose-dependent manner (Fig. 1d).

1999年10月1日 · The MMP-9 promoter has several transcription factor binding motifs, including those for AP-1, ETS family members, Sp -1, and NF-KB [18,19]. Coordinate activation of these sites was required for regulation of promoter activity by tumor necrosis factor or phorbol esters [12,13]. Both ETS and AP-1 sites were required for ras-induced upregulation ...

2013年7月7日 · Background: Matrix metalloproteinase 9 is involved in fear-associated memory formation wherein transcriptional regulation is poorly known. Results: Overexpression and promoter binding activity of AP-1 factors regulate MMP-9 transcription, preceding elevated enzymatic activity in mouse brain. Conclusion: c-Fos and c-Jun AP-1 components positively regulate MMP-9 transcription in fear learning.

在神经科学领域，c-FOS蛋白通常被当做神经元活性的标志物，但它最初是在40年前于大鼠的成纤维细胞中被发现的，c-FOS蛋白由原癌基因编码，并在多种肿瘤细胞中过表达。c-FOS是一个转录因子，其主要作用是调节细胞核…

However, as already mentioned, MMP-9 gene expression seems to be modulated in a cell type/stimulus-specific manner. Our results demonstrate that MMP-9 transcription is increased by synaptic activity and is dependent on TrkB signaling. It has been shown that increasing synaptic activity with bicuculline induces the expression of BDNF (50–52 ...

Furthermore, as the c-Fos gene is a known target of serum response factor (SRF), we investigated whether SRF contributes to MMP-9 transcription. Inhibition of SRF and its cofactors by either overexpression of dominant negative mutants or shRNA decreased MMP-9 promoter activation. In contrast, MMP-9 transcription was not dependent on CREB activity.

T-5224 是选择性的转录因子 c-Fos/activator protein (AP)-1 抑制剂，具有抗炎活性，能特异性抑制 c-Fos/c-Jun 的 DNA 结合活性，而不影响其他转录因子的结合活性。T-5224 抑制 IL-1β 诱导的 Mmp-3、Mmp-13、Adamts-5 转录上调。- 高纯度，全球文献引用。

胶原蛋白分解基质金属蛋白酶（mmps）-1和mmp-13导致的不可逆软骨胶原蛋白分解是与组织破坏（如关节炎）相关的病理学中的关键事件。 ... 此外，在类似于cfos的mrna和蛋白水平上，csrnp1的表达出现了一个短暂的峰值，随后与cfos不同，csrnp1的表达持续存在。

Increased expression of MMP-9 has been associated with acquisition of invasive phenotype in many tumors. However, multiple mechanisms for regulation of MMP-9 gene expression by tumor cell lines have been proposed. A number of transcription factor binding sites have been characterized in the upstream regulatory region of the MMP-9 gene ...