During embryonic development, MMP-13 is expressed in the skeleton as required for restructuring the collagen matrix for bone mineralization. In pathological situations it is highly overexpressed; this occurs in human carcinomas, rheumatoid arthritis and osteoarthritis.

Her research showed that degeneration is caused by perturbations in the epidermis due to an increase in matrix-metalloproteinase 13 (MMP-13), an enzyme that degrades the collagen, or “glue,” between the cells.

2024年12月25日 · MMP13 (Matrix Metallopeptidase 13) is a Protein Coding gene. Diseases associated with MMP13 include Spondyloepimetaphyseal Dysplasia, Missouri Type and Metaphyseal Dysplasia, Spahr Type. Among its related pathways are Gene expression (Transcription) and Collagen chain trimerization.

2024年4月2日 · I have read several articles on MMP-13 and how it affects our bodies interesting. Why has this been buried? The second thing I looked at was a research done with alpha lipoic acid and neuropathy.

2017年11月10日 · In this review, we highlight the main MMP-13-related changes in OA chondrocytes, including alterations in the activity and expression level of MMP-13 by upstream regulatory factors, DNA methylation, various non-coding RNAs (ncRNAs), and autophagy.

2021年2月9日 · Matrix metalloproteinase-13 (MMP-13) is the primary MMP involved in cartilage degradation through its particular ability to cleave type II collagen. Hence, it is an attractive target for the treatment of OA.

2025年2月10日 · Matrix metalloproteinase 13 (MMP13) plays a crucial role in neuropathy, impacting both tissue remodeling and neuroinflammation. Understanding MMP13’s involvement is vital as it contributes to the progression of various neurological disorders by …

2013年1月8日 · Here, we tested the role of MMP13 using Mmp13 cKO mice and using a MMP13 inhibitor in a surgically induced OA mouse model. Our studies suggest that inhibition of MMP13 expression or activity could efficiently prevent and decelerate OA progression.

2025年3月14日 · Explore how plant and marine-derived compounds interact with MMP-13, offering insights into natural inhibition mechanisms and potential research applications. Matrix metalloproteinase-13 (MMP-13) plays a crucial role in tissue remodeling and degradation, particularly in conditions like osteoarthritis and cancer.

A gene on chromosome 11q22.3 that encodes matrix metalloproteinase 13, which cleaves collagens I in the extracellular matrix. MMP13 may play a role in turnover of articular cartilage. Molecular pathology. Defects in MMP13 cause spondyloepimetaphyseal dysplasia Missouri type and metaphyseal anadysplasia type 1.