2023年11月2日 · While HSPC harbor primary disease driver mutations, MSC in myelodysplastic syndrome and myeloproliferative neoplasm (MDS/MPN) have been shown to influence the …

2017年8月10日 · There is evidence of continuous bidirectional cross-talk between malignant cells and bone marrow-derived mesenchymal stromal cells (BM-MSC), which favors the emergence …

2017年8月10日 · There is evidence of continuous bidirectional cross-talk between malignant cells and bone marrow-derived mesenchymal stromal cells (BM-MSC), which favors the emergence …

2021年4月1日 · We aimed to generate a comprehensive map of the stroma in MPNs/MFs on a single-cell level in murine models and patient samples. Our analysis revealed two distinct …

2024年2月15日 · PV and ET patients-derived MPN-MSCs consistently display altered expression patterns of genes linked to healthy blood cells, including overexpression of SPP1 and NF-κB …

2023年11月2日 · We examined BM samples from MDS/MPN patients with high rate of leukemic transformation in less than 2 years (HR) versus those with stable disease for 5 years (SD), to …

2017年4月25日 · Histone deacetylases (HDACs) are involved in epigenetic modulation and their aberrant expression has been demonstrated in myeloproliferative neoplasms (MPN). HDAC8 …

2017年8月10日 · There is evidence of continuous bidirectional cross-talk between malignant cells and bone marrow-derived mesenchymal stromal cells (BM-MSC), which favors the emergence …

2014年12月14日 · Once activated, MPN-MSC acquire a secretory phenotype that facilitates MSC migration, matrix contraction and provides a provisional matrix for collagen (Col) fibres in more …

There is evidence of continuous bidirectional cross-talk between malignant cells and bone marrow-derived mesenchymal stromal cells (BM-MSC), which favors the emergence and …