In the context of IBD, myeloperoxidase (MPO), a lysosomal protein found in neutrophils, may serve as a viable biomarker for assessing disease status. Several studies demonstrated increased levels of neutrophils in patients with active IBD.

2018年5月1日 · Targeting MPO may mitigate oxidative damage to host tissue and ensuing inflammation. Here we identify mechanisms by which MPO activity perpetuates inflammation and contributes to host-tissue injury in patients with IBD and discuss MPO as a potential therapeutic target to protect the colon from inflammatory injury.

现有研究显示，ibd患者的髓过氧化物酶（mpo）水平显著升高并与疾病严重程度相关。mpo主要表达在肠道粘膜的浸润的中性粒细胞之中，能够消耗过氧化氢（h2o2）进而氧化氯离子（cl-）产生次氯酸（hocl）。

中性粒细胞髓过氧化物酶 （MPO） 是一种丰富的颗粒酶，可催化产生有效的 ROS;IBD 患者粘膜中氧化损伤 （和 MPO 蛋白） 的生物标志物增加。 靶向 MPO 可以减轻对宿主组织的氧化损伤和随之而来的炎症。 在这里，我们确定了 MPO 活性使炎症持续存在并导致 IBD 患者宿主组织损伤的机制，并讨论了 MPO 作为保护结肠免受炎症损伤的潜在治疗靶点。 炎症性肠病 （IBD） 是一种涉及胃肠道炎症的使人衰弱的疾病。 IBD 的发病率在世界范围内呈上升趋势。 胃肠道 （GI） 对 …

2021年9月1日 · Mechanisms have been proposed by which MPO activity perpetuates inflammation and contributes to tissue damage in patients with IBD, including depletion of endogenous antioxidant effectors and HOCl-mediated cell hyperphosphorylation and enhancement inflammation via PTEN inactivation [66].

2017年1月31日 · In the context of IBD, myeloperoxidase (MPO), a lysosomal protein found in neutrophils, may serve as a viable biomarker for assessing disease status. Several studies demonstrated increased levels of neutrophils in patients with active IBD.

2022年7月8日 · Inflammatory bowel disease [IBD], consisting of Crohn’s disease [CD] and ulcerative colitis [UC], is a relapsing-remitting illness. Treat-to-target IBD management strategies require monitoring of gastrointestinal inflammation. This study aimed to investigate faecal myeloperoxidase [fMPO], a neutrophil granule enzyme, as a biomarker of IBD activity.

We conducted a comprehensive overview of oxidative stress markers (OSMs) as potential diagnostic, differential, progression, and prognostic markers in IBD. A Pubmed, Web of Knowledge, and Scopus search of original articles on OSMs in IBD, published between January 2000 and April 2020, was conducted.

粪便钙卫蛋白 (fCal) 是一种中性粒细胞胞浆蛋白，作为 IBD 中的生物标志物得到了广泛研究。 此外髓过氧化物酶 (MPO) 是另一种丰富的中性粒细胞颗粒，MPO通过产生强氧化剂次氯酸，在杀灭细菌和促进炎症组织损伤方面发挥重要作用。

2024年10月1日 · The neutrophilic proteins were superior to EDN in the fecal samples for differentiating between patients with IBD and IBS. Fecal MPO (cutoff: 0.86 mg/kg) had the highest sensitivity (74.7%) and specificity (84.6%). Combining fecal CP and MPO increased the sensitivity to 82.3% (specificity: 73.6%).