2019年11月13日 · Positive test results for ANCA, PR3, and/or MPO help support a diagnosis of systemic autoimmune vasculitis and distinguish between different types of vasculitis. However, to confirm a diagnosis, a biopsy of an affected site is often required.

2015年10月17日 · 抗中性粒细胞抗体（ANCA）直接针对蛋白酶 3（PR3）或髓过氧化物酶（MPO）。 在过去的几十年中又有不断涌现的证据来证明 PR3-ANCA 相关性血管炎（PR3-AAV）和 MPO-ANCA 相关性血管炎（MPO-AAV）之间的差别。 来自荷兰马斯特里赫特大学实验和临床免疫学的 Marc Hilhorst 教授在 JASN 上发表综述讨论了这两种小血管受累的血管炎之间的差别，我们一起来学习一下。 抗中性粒细胞抗体（ANCA）在 50 多年前首次被描述。 稍后这 …

Concurrent testing for serum antineutrophil cytoplasmic antibodies (ANCA) by indirect immunofluorescence (IF) and by anti-proteinase-3 (PR3)/anti-myeloperoxidase (MPO) antibody assays may identify patients with PR3-ANCA or MPO-ANCA despite a negative IF (IF-negative MPO/PR3-positive); however, the significance of this result is not clear.

For the workup of suspected vasculitis, refer to ANCA-Associated Vasculitis Profile (ANCA/MPO/PR3) . For patients with a history of vasculitis, refer to Myeloperoxidase (MPO) Antibody and Serine Proteinase 3 (PR3) Antibody with Reflex to Anti-Neutrophil Cytoplasmic Antibody, IgG by IFA .

mpo - anca和pr3 - anca是两种主要的anca类型。它们在发病机制上与自身免疫反应导致的小血管炎密切相关。mpo主要针对髓过氧化物酶，pr3主要针对蛋白酶3，这两种抗体分别介导不同的病理生理过程。 通常情况下，疾病往往以mpo - anca或pr3 - anca阳性为主。

2024年9月30日 · Positive ANCA, PR3, and/or MPO tests help to support a diagnosis of systemic autoimmune vasculitis and to distinguish between different types. However, to confirm a diagnosis, a biopsy of an affected site is most often required.

2024年8月11日 · Both ANCA-myeloperoxidase (MPO) and ANCA-proteinase 3 (PR3) are enzymes present in peroxidase-positive granules, and MPO is the most prevalent granular protein. PR3 is important for serving as a hematopoietic regulator …

2024年4月1日 · Engagement of ANCA with both the autoantigen (MPO or PR3) and Fcγ-receptor on the surface of cytokine-primed and C5a-primed neutrophils induces full activation, respiratory burst, neutrophil extracellular trap release, and degranulation of adherent neutrophils with endothelial cell damage.

anca特异性自身抗体的靶抗原包括mpo、pr3、hle、lf、lys、cath g及bpi等。其中临床主要检测抗mpo抗体和抗pr3抗体，对aav的分型、临床表现、治疗反应及预后判断具有重要的临床意义 ，并且其量值改变可用于aav患者病情监测。因此，建议对抗mpo抗体和抗pr3抗体进行定量 ...

2014年11月25日 · 结果在10例ANCA相关小血管炎患者中，肾病综合征、慢性肾炎、急性肾炎、系统性红斑狼疮、韦格纳肉芽肿和未分类小血管炎的抗MPO，PR3，GBM联合检测的阳性率分别是5.4%、83.6%、50.0%、57.%、40.0%和8.6%；而60例健康者未检出此三种抗...