Distinct signaling pathways regulate transformation and inhibition …
In this study, we investigated MAP kinase activity in control 23A2 myoblasts and in 23A2 myoblasts rendered differentiation-defective by the stable expression of an oncogenic …
RASopathies – what they reveal about RAS/MAPK signaling in …
2024年6月7日 · RASopathies are rare, single-gene, autosomal dominant (or rarely autosomal recessive) disorders caused by germline pathogenic variants in the genes that encode …
Distinct signaling pathways regulate transformation and inhibition …
1997年2月13日 · In this study, we investigated MAP kinase activity in control 23A2 myoblasts and in 23A2 myoblasts rendered differentiation-defective by the stable expression of an oncogenic …
(PDF) Distinct signaling pathways regulate transformation and ...
1997年3月1日 · In this study, we investigated MAP kinase activity in control 23A2 myoblasts and in 23A2 myoblasts rendered differentiation-defective by the stable expression of an oncogenic …
Ras regulation of skeletal muscle differentiation and gene expression
2001年1月1日 · Ras proteins inhibit the expression of the muscle regulatory factors [MRFs: members of the basic helix-loop-helix (bHLH) transcription factor family] in both primary …
RAS Proteins and Their Regulators in Human Disease
2017年6月29日 · RAS proteins are binary switches, cycling between ON and OFF states during signal transduction. These switches are normally tightly controlled, but in RAS-related …
Function of the myogenic regulatory factors Myf5, MyoD, Myogenin …
2017年12月1日 · The ≥69% homology in the 59 amino acid sequence of the bHLH domains of the single nematode MRF (Cel-MyoD) compared to chick and mouse MYF5, MYOD, MRF4 and …
Dynamic regulation of RAS and RAS signaling - PMC - PubMed …
Starting from the structural and biochemical properties of wild-type and mutant RAS proteins and their activation cycle, we examine higher molecular assemblies, effector interactions and …
EGF, activation of FKBP-Raf by FK1012A is entirely Ras-GTP dependent. Thus oligomerization of. 4-3-3( with a potential activator bound to the second 14-3-3 protein. To deter mine whether …
r eukaryotic ARF proteins8, and their function and interactions are probably highly conserved. We constructed two mutants of the ARF2 gene: G29A and T31N, in which glycine i. replaced by …