2024年9月1日 · MRX-2843 is a promising inhibitor of FLT3 and MERTK. We recently demonstrated that MRX-2843 is equally potent as gilteritinib in FLT3-ITD AML cell lines in vitro …

2022年9月3日 · Both gilteritinib and MRX-2843 in combination with AZD5991 show synergistic antileukemic activity against AraC-resistant FLT3-mutated AML cells. Our findings provide …

AZD5991 enhances the antileukemic activity of the FLT3 inhibitors gilteritinib and MRX-2843 against FLT3-mutated AML in vitro, warranting further development. FMS-like tyrosine kinase …

MER tyrosine kinase (MERTK), a member of the TAM (TYRO3, AXL, MERTK) P1.12A.10 family of receptor tyrosine kinases mediates resistance to osimertinib. MRX-2843 is a novel small …

2022年9月3日 · FLT3 inhibitors have been developed to treat patients with FLT3-mutated AML and have shown promise, though the acquisition of resistance occurs, highlighting the need for …

2021年5月12日 · The BAT motif inhibits the ability of the Mre11-Rad50-Xrs2 complex (MRX) to capture DNA ends. It acts through a direct contact with Rad50 ATP-binding Head domains.

2016年3月18日 · A novel compound MRX-2843 more than doubled the median days of survival in laboratory models with a drug-resistant form of the acute myeloid leukemia, scientists report in …

2022年8月1日 · The MERTK ligand GAS6 promoted downstream oncogenic signaling in EGFR-mutated (EGFRMT) NSCLC cells treated with OSI, suggesting a role for MERTK activation in …

2024年9月1日 · In this study, we investigated the combination of VEN and MRX-2843 against FLT3 -ITD AML cells. We found that VEN synergistically enhances cell death induced by MRX …

2007年5月4日 · We linked a new MRX condition, MRX87, to Xp22-Xp21 interval. This is one of the three hot spot regions for X-linked mental retardation containing ARX, a gene prominently …