2024年11月27日 · What causes PIRA, or progression independent of relapse activity? Learn more about smoldering MS and new research on neurodegeneration and PIRA treatments.

2023年4月6日 · Progression Independent of Relapse Activity (PIRA) is heterogeneously described in patients with multiple sclerosis (MS) regarding the frequency and nature of PIRA. …

2024年6月18日 · Progression independent of relapse activity (PIRA), a recent concept to formalize disability accrual in multiple sclerosis (MS) independent of relapses, has gained …

A new term in MS research that has emerged in recent years is PIRA, or progression independent of relapse activity. It purports to quantify the proportion of disability worsening due to non …

2024年5月15日 · Disability progression independent of relapse activity (PIRA) -- sometimes referred to as silent progression -- is a key integrating concept in the contemporary view of...

The currently available research supports the presence of PIRA in relapsing MS. Based on review of the existing literature, we propose a definition of PIRA that is clinically relevant and …

2023年6月23日 · Detailed exploration of studies evaluating the use of highly effective treatments have unveiled the clinical concept of progression independent of disease activity (PIRA), or an …

2023年11月1日 · PIRA is the most frequent manifestation of disability accumulation across the full spectrum of traditional MS phenotypes, including clinically isolated syndrome and early RRMS. …

Progression independent of relapse activity (PIRA) is an established phenomenon in relapsing-remitting multiple sclerosis (RRMS). 5-11*† PIRA is responsible for up to 80% to 90% of …

Accumulation of disability in multiple sclerosis may occur as relapse-associated worsening (RAW) or steady progression independent of relapse activity (PIRA), with PIRA regarded as a feature …