2023年7月15日 · What does an MSH2 mutation mean for my blood relatives? If you have a mutation, your biological parents, siblings, and children each have a 50% chance of having the …

The MSH2 gene provides instructions for making a protein that plays an essential role in repairing DNA. This protein helps fix errors that are made when DNA is copied (DNA replication) in …

2024年12月25日 · MSH2 (MutS Homolog 2) is a Protein Coding gene. Diseases associated with MSH2 include Lynch Syndrome 1 and Muir-Torre Syndrome. Among its related pathways are …

2022年8月23日 · Finding out you have an MSH2 gene mutation can be useful information for your family members. It can also help you better understand your cancer risk. Men and women with …

2024年9月6日 · MSH2 inherited mutations (Lynch Syndrome) may affect your options for cancer prevention, detection and treatment. FORCE is here to guide you.

Understanding Your Positive MSH2 Genetic Test Result information for patients with a pathogenic or likely pathogenic variant There is a 50/50 random chance to pass on the pathogenic or …

Pediatric high-grade glioma (pedHGG) can occur as first manifestation of cancer predisposition syndromes resulting from pathogenic germline variants in the DNA mismatch repair (MMR) …

MSH2 is the very young onset ovarian cancer predisposition gene, not BRCA1. Comprehensive RNA and protein functional assessments contribute to the clinical interpretation of MSH2 …

People with an inherited MSH2 mutation may have an increased risk for other cancers. The exact risks for the following cancers are unknown: pancreatic cancer; sebaceous skin growths; …

MSH2 and MSH6 share five similar domains, but with sufficient differences to give MSH6 several distinct functions. MSH6 also has a unique N-terminal disordered domain that is absent in its …