DNA mismatch repair protein, MutS Homolog 3 (MSH3) is a human homologue of the bacterial mismatch repair protein MutS that participates in the mismatch repair (MMR) system. MSH3 typically forms the heterodimer MutSβ with MSH2 in order to correct long insertion/deletion loops and base-base mispairs in microsatellites during DNA synthesis.

2024年12月25日 · MSH3 (MutS Homolog 3) is a Protein Coding gene. Diseases associated with MSH3 include Familial Adenomatous Polyposis 4 and Endometrial Cancer. Among its related pathways are DNA repair pathways, full network and …

MutS homolog 3 (MSH3) is a gene that encodes a protein that is a component of MutS beta - a post-replicative DNA mismatch repair system. The protein functions in DNA mismatch repair. Missense mutations, nonsense mutations, silent mutations, frameshift deletions and insertions, and in-frame deletions are observed in cancers such as intestinal ...

错配修复 (Mismatch Repair，MMR) 是指在含有错配碱基的 DNA 分子中，使核苷酸序列恢复正常的修复方式。 当 MMR 基因发生胚系突变或甲基化时将导致 MMR 功能下降，致使 DNA序列中的碱基错配、缺失或插入不能被修复。 因此， MMR 系统是体内的一个安全保障体系，它可以维持遗传物质的完整性和稳定性。 MMR 系统在参与 DNA 修复时可涉及到多个错配修复蛋白，包括 MutS （MSH2 、MSH3 和 MSH6 等）和 MutL （MLH1 、MLH3、PMS1 和 PMS2）两大家族。 其 …

2022年2月28日 · The MSH3 gene helps protect the body from cancers. Learn more about MSH3 and the possible genetic variants that impact cancer risk.

2024年1月19日 · We describe here an individual from a fourth family with germline compound heterozygous MSH3 germline variants and its observed biological consequences. The patient was initially diagnosed with...

2025年1月4日 · Title: Novel insights into the ecDNA formation mechanism involving MSH3 in methotrexate‑resistant human colorectal cancer cells. MSH2-MSH3 promotes DNA end resection during homologous recombination and blocks polymerase theta-mediated end-joining through interaction with SMARCAD1 and EXO1.

MSH3: a confirmed predisposing gene for adenomatous polyposis. Novel insights into the ecDNA formation mechanism involving MSH3 in methotrexate-resistant human colorectal cancer cells. MSH2-MSH3 promotes DNA end resection during homologous recombination and blocks polymerase theta-mediated end-joining through interaction with SMARCAD1 and EXO1.

2016年8月29日 · Fujii and Shimada (1989) identified a gene encoding human homolog of the bacterial mismatch repair protein MutS upstream of the dihydrofolate reductase (DHFR; 126060) gene on chromosome 5q11.2-q13.2. The amino acid sequence encoded by this gene, referred to by them as hMSH3, has 31% identity with that of MutS.

2024年11月2日 · Clinical resource with information about MSH3, Endometrial carcinoma, Familial adenomatous polyposis 4, and available tests. There are links to practice guidelines and authoritative resources like GeneReviews, PubMed, MedlinePlus, PharmGKB and clinicaltrials.gov.