MSH4 Gene - GeneCards | MSH4 Protein | MSH4 Antibody
2024年12月25日 · MSH4 (MutS Homolog 4) is a Protein Coding gene. Diseases associated with MSH4 include Premature Ovarian Failure 20 and Spermatogenic Failure 2. Among its related …
MSH4 - Wikipedia
MutS protein homolog 4 is a protein that in humans is encoded by the MSH4 gene. [5][6] The MSH4 and MSH5 proteins form a hetero-oligomeric structure (heterodimer) in yeast and …
Reducing MSH4 copy number prevents meiotic crossovers between …
2019年5月29日 · Here, we show that reducing the number of functional copies of MSH4, an essential gene for the main crossover pathway, prevents non-homologous crossovers in …
Identification of compound heterozygous variants in MSH4 as a …
2023年8月24日 · In this study, we present evidence of biallelic variants in MSH4 as a potential cause of DOR. Our findings indicate a correlation between MSH4 variants and reduced oocyte …
SUMO fosters assembly and functionality of the MutSγ complex …
2021年7月26日 · Here we identify Msh4 as a target of SUMO-mediated crossover regulation. Msh4 and Msh5 constitute the MutSγ complex, which stabilizes joint-molecule (JM) …
Regulated Proteolysis of MutSγ Controls Meiotic Crossing Over
2020年4月2日 · Recombination factor MutSγ (Msh4-Msh5) is regulated by a degron that directly targets Msh4 for ubiquitin-independent proteasomal proteolysis. Degron phosphorylation by …
4438 - Gene ResultMSH4 mutS homolog 4 [ (human)] - National …
A novel homozygote nonsense variant of MSH4 leads to primary ovarian insufficiency and non-obstructive azoospermia. Identification of compound heterozygous variants in MSH4 as a …
MutS homolog 4 localization to meiotic chromosomes is required …
2000年5月1日 · Msh4 (MutS homolog 4) is a member of the mammalian mismatch repair gene family whose members are involved in postreplicative DNA mismatch repair as well as in the …
mutS 同系物 4（MSH4）基因 | MCE - MCE-生物活性分子大师
该蛋白和 MSH5 形成异二聚体，该异二聚体独特地结合霍利迪连接点及其发育祖细胞，从而激发 ADP-ATP 交换，并在减数分裂双链断裂修复过程中稳定亲本染色体之间的相互作用。 [RefSeq …
MSH4人源基因|MSH4基因突变_致病性_靶点-RDDC官网
Novel bi-allelic MSH4 variants causes meiotic arrest and non-obstructive azoospermia. 这个基因编码DNA错配修复mutS家族的一员。 这个成员是一种有丝分裂特异性的蛋白质，不参与DNA …