2024年12月25日 · MST1 (Macrophage Stimulating 1) is a Protein Coding gene. Diseases associated with MST1 include Immunodeficiency 14 and Cholangitis, Primary Sclerosing . Among its related pathways are Hippo-Merlin signaling dysregulation and MSP-RON Signaling .

Mammalian Mst1 and Mst2 kinases play essential role in the regulation of cellular redox state. See text for details.

2013年8月28日 · The serine/threonine protein kinases Mst1 and Mst2, mammalian homologs of the Hippo kinase from Drosophila, play the central roles in the Hippo pathway controlling the cell proliferation, differentiation, and apoptosis during development.

2024年11月22日 · MST1 knockdown and chemical inactivation reduced cognitive decline, mitochondrial dysfunction, and neuronal degeneration. Mechanistically, MST1 regulated the transcription of mitochondrial genes, including MT-ND4L, MT …

Mammalian STE20-like kinase-1 (Mst1) is a generally expressed apoptosis-promoting kinase and a key bridge-builder of apoptotic signaling in the etiology of tissue injury.

Mammalian sterile 20-like kinase 1 (MST1) is a protein kinase, and the occurrence of many heart diseases is related to the continuous activation of the MST1 gene. With the deepening of the research, the potential role of MST1 in promoting the development of …

MST1 or MST2 overexpression was also found to consistently induce apoptosis; moreover, apoptosis activated the endogenous MST1/MST2 kinases, 4–9 responses suggestive of a physiologic role for these kinases in effecting apoptosis.

2025年1月4日 · Title: Mst1-mediated phosphorylation of Nur77 improves the endometrial receptivity in human and mice. Macrophage-stimulating protein is decreased in severe preeclampsia and regulates the biological behavior of HTR-8/SVneo trophoblast cells.

2024年7月25日 · Here we show that Mst1 phosphorylates FoxO1 Ser209/Ser215/Ser218/Thr228/Ser232/Ser243, thereby inhibiting FoxO1-mediated transcription of proapoptotic genes. On the other hand, Mst1 increases...

2014年3月16日 · We show MST1 as a proapoptotic kinase and key mediator of apoptotic signaling and beta cell dysfunction and suggest that it may serve as target for the development of new therapies for...