核酸氧化损伤修复酶MTH1及其抑制剂的研究进展
MTH1酶即MutT同源酶1(MutT homolog 1)，属于Nudix(nucleoside diphosphate linked to x)水解酶超级家族，是由NUDT1基因表达所得的8-羟基鸟嘌呤核苷酸酶，其国际生物化学联合会酶学 …
MTH1 protects platelet mitochondria from oxidative damage and …
2023年8月10日 · Human MutT Homolog 1 (MTH1) is a nucleotide pool sanitization enzyme that hydrolyzes oxidized nucleotides to prevent their mis-incorporation into DNA under oxidative...
2-hydroxy-dATP diphosphatase - Wikipedia
2-hydroxy-dATP diphosphatase (EC 3.6.1.56, also known as oxidized purine nucleoside triphosphatase, or (2'-deoxy) ribonucleoside 5'-triphosphate pyrophosphohydrolase, or Nudix …
MTH1 inhibition eradicates cancer by preventing sanitation of
2014年4月2日 · We validate MTH1 as an anticancer target in vivo and describe small molecules TH287 and TH588 as first-in-class nudix hydrolase family inhibitors that potently and …
靶向 MTH1：过敏性气道炎症治疗的新曙光 - 生物通
2 天之前 · mth1 在细胞内负责清除 ros 损伤的 dntps，防止氧化的 dntps 掺入 dna，维持细胞的正常功能。当细胞增殖或发生炎症时，ros 水平升高，mth1 表达也会上调，这使得高表达 mth1 …
Targeting the nucleic acid oxidative damage repair enzyme MTH1: …
MTH1 functions by hydrolyzing oxidized deoxyribonucleoside triphosphates, thereby preventing the incorporation of oxidized dNTPs into DNA during replication and maintaining normal cell …
MTH1 protects platelet mitochondria from oxidative damage and …
2023年8月10日 · Human MutT Homolog 1 (MTH1) is a nucleotide pool sanitization enzyme that hydrolyzes oxidized nucleotides to prevent their mis-incorporation into DNA under oxidative …
MTH1 在氧化应激和癌症治疗靶向中的作用,Redox Biology - X-MOL
mth1 水平在许多癌症中通常升高，因此，抑制 mth1 是抑制肿瘤生长和转移的一种有吸引力的策略。靶向 mth1 抑制可在癌细胞中诱导 dna 损伤，利用它们对氧化应激的脆弱性并选择性地靶向 …
靶向MTH1治疗肿瘤的研究进展 - 仁和软件
最新的研究表明,MTH1可以清除肿瘤细胞中受损DNA功能结构的氧化构件,使得肿瘤细胞继续分裂与增殖,从而维持肿瘤细胞的生存,而更为重要的是正常细胞不需要MTH1,因此,MTH1有可能只与 …
MTH1抑制剂在癌症治疗中的研究进展 - 汉斯出版社
MTH1 (MutT homolog 1) can effectively sanitize oxidized nucleotides in the nucleotides pool to pro-tect cancer cells from fatal damage caused by high levels of ROS (reactive oxygen …