2023年5月22日 · High-resolution 3T/7T MRI of the brain with thin cuts obtained through the temporal lobes is a powerful tool to assess subtle structural abnormalities involving the mesial temporal structures. Additional information regarding hippocampal pathology is obtainable with the use of multiple MR modalities such as volumetry, spectroscopy, and ...

2024年12月8日 · MRI. MRI is the modality of choice to evaluate the hippocampus, however dedicated temporal lobe epilepsy protocol needs to be performed if good sensitivity and specificity is to be achieved 5. Thin section angled coronal sequences at right angles to the longitudinal axis of the hippocampus are required, to minimize volume averaging.

2013年6月1日 · Mesial temporal lobe epilepsy (MTLE) is the most common of the surgically remediable drug-resistant epilepsies. MRI is the primary diagnostic tool to detect anatomical abnormalities and, when combined with EEG, can more accurately identify an epileptogenic lesion, which is often hippocampal sclerosis in cases of MTLE.

2021年5月3日 · In this work we investigated brain organization models specifically related to unilateral mesial temporal lobe epilepsy (mTLE) as a framework on which MRI functional and structural connectivity changes occur over time and space in these patients. In mTLE, seizures originate within one hippocampus and propagate across the brain (Engel, 2001).

Objective: We aimed to investigate patterns of electroencephalography-correlated functional MRI (EEG-fMRI) and subtle structural abnormalities in patients with mesial temporal lobe epilepsy (MTLE) with hippocampal sclerosis (MTLE-HS) or normal MRI (MTLE-NL).

Medial temporal lobe epilepsy (MTLE) is associated with network pathology in gray and white matter regions connected to the epileptogenic hippocampus. 1 The thalamus is the most consistent site of extrahippocampal gray matter loss in structural magnetic resonance imaging (MRI) studies of MTLE with hippocampal sclerosis (MTLE-HS). 2 White matter ...

2004年7月1日 · MRI-based evaluation of the hippocampus is important in the assessment and treatment of patients with mesial temporal lobe epilepsy (MTLE). Using MRI-based large-deformation high-dimensional mapping (HDM-LD), which allows structural evaluation of regions of the hippocampus, we document the HDM-LD-defined pattern of hippocampal deformation in ...

本文将综述与TLE生物标志物有关的定量MRI原理及其在TLE诊疗和癫痫网络研究中的应用进展，旨在协助TLE诊疗过程中精确定位致痫灶、评估病变程度，并制订个体化治疗方案。 T1与T2加权图像对比度源于质子固有弛豫特性的差异，即纵向弛豫时间和横向弛豫时间，其在一定温度和条件下保持不变 [11]。 与标准T1和T2加权成像相比，通过T1、T2 mapping直接测量组织的定量纵向弛豫时间（quantitative T1, qT1）以及定量横向弛豫时间（quantitative T2, qT2），具有更好地 …

2014年11月13日 · Results from selected volumetric and morphometric MRI studies that have addressed the relationship between preoperative brain structure and postoperative seizure outcome in patients with TLE. mTLE is indicated for samples with electrophysiological evidence of TLE and concomitant ipsilateral HS.

2021年4月27日 · We measured MRI network progression in mesial temporal lobe epilepsy (mTLE) patients as a function of healthy brain architecture. Resting-state functional MRI and diffusion-weighted MRI were acquired in 40 unilateral mTLE patients and 70 healthy controls. Data were used to construct region-to-region …