Klp2-mediated Rsp1-Mto1 colocalization inhibits microtubule
2025年1月3日 · Our results suggest that Klp2 regulates the activity of noncentrosomal MTOCs by targeting Rsp1 to the sites of Mto1 activity and reveal a mechanism for the inhibition of …
The genotypic and phenotypic spectrum of MTO1 deficiency
MTO1 (Mitochondrial tRNA Translation Optimization 1), an evolutionarily conserved protein expressed in high-energy demand tissues has been linked to human early-onset combined …
MTO1 Gene - GeneCards | MTO1 Protein | MTO1 Antibody
2024年12月25日 · MTO1 (Mitochondrial TRNA Translation Optimization 1) is a Protein Coding gene. Diseases associated with MTO1 include Combined Oxidative Phosphorylation …
Mitochondrial translation regulates terminal erythroid …
2025年2月21日 · We demonstrated that a Mto1 deficiency resulted in reduced formation of OXPHOS complexes and altered intracellular iron homeostasis, which resulted in the up …
线粒体 tRNA 翻译优化 1（MTO1）基因 | MCE - MCE-生物活性 ...
该基因编码一种被认为参与线粒体 tRNA 修饰的线粒体蛋白。 编码的蛋白质也可能在与线粒体 12S rRNA 基因的特定突变相关的非综合征和氨基糖苷类诱导的耳聋表型的表达中发挥作用。 已发 …
Two distinct regions of Mto1 are required for normal microtubule ...
2008年12月1日 · Our cytological and biochemical analysis of mto1-9A1, mto1-9A2, and mto1-334 mutants demonstrates that two distinct regions of Mto1—the CM1 region and the Mto2-binding …
Effects of the microtubule nucleator Mto1 on chromosomal movement…
2019年10月1日 · Mto1 is a cytoplasmic factor that mediates the nucleation and attachment of cytoplasmic MTs to the nucleus. Here, we test the function of these cytoplasmic MTs and Mto1 …
MTO1基因新位点突变致复合型氧化磷酸化缺陷症10型1例 - 中华 …
本研究报道1例 MTO 1基因突变导致的COXPD10病例，其初发临床表现和突变位点与现有文献报道均有不同之处；并进行相关文献复习，以加深临床医师对该类疾病的认识，更好地进行早期 …
MTO1 mitochondrial tRNA translation optimization 1 [ (human)]
2025年2月8日 · MTO1 mediates tRNA modification and controls mitochondrial translation rate in a highly tissue-specific manner associated with tissue-specific oxidative phosphorylation defects. …
Fission Yeast Mto1 Regulates Diversity of Cytoplasmic …
2010年11月9日 · Here we identify a short conserved C-terminal sequence in Mto1, termed MASC, important for targeting Mto1 to multiple distinct MTOCs. Different subregions of MASC target …