TEM photographs of various-sized lysosomes, multivesicular bodies (MVBs), autophagosomes and a few lipid droplets. (A) MVB endocytosed by a lysosome. The inset shows the dilation of the MVB...

2019年12月13日 · Here we describe how live imaging with tetraspanin-based pH-sensitive fluorescent reporters can quantify the MVB–PM fusion rate of single cells. Our approach enables identification of exogenous...

2017年2月3日 · We previously observed by transmission electron microscopy (TEM) that multivesicular bodies (MVBs) accumulate in the trophectoderm of activated blastocysts that were released from the delayed...

2008年11月14日 · Currently, clear evidence suggests that efficient autophagic degradation requires functional MVBs. This review highlights the most recent advances in our understanding of the molecular machinery...

MVB指的是多囊体（Multivesicularbody），是溶酶体产生过程中由一个大膜泡包裹小膜泡形成的小体，其也常常作为大多数溶酶体和晚期内小体的统称。 早期内小体成熟的一个关键特征是MVBs的形成。 MVB指的是多囊体（Multivesicularbody），是溶酶体产生过程中由一个大膜泡包裹小膜泡形成的小体，其也常常作为大多数溶酶体和晚期内小体的统称。

Download scientific diagram | Electron microscopy of multivesicular bodies (MVB) and small extracellular vesicles (sEVs) (a) TEM micrograph of multivesicular bodies with intraluminal vesicles...

Multivesicular bodies (MVB) originate from endosomes. They fill a large portion of the cytoplasm of gland cells. In TEM pictures, the degradation of their content...

2017年7月21日 · 细胞多泡小体（mvb）内的膜泡具有形态多样性 为了研究HMC-1细胞系产生的外泌体的形态特征，采用多种电子显微技术。 如材料与方法部分所述，HMC-1细胞在高压冷冻、冷冻置换和切片后成像。

For lysosomal degradation, ubiquitination triggers the sorting of cargo proteins into the lumen of late endosomal multivesicular bodies (MVBs)/endosomes. MVB formation occurs when a portion of the limiting membrane of an endosome invaginates and buds into its own lumen. Intralumenal vesicles are degraded when MVBs fuse to lysosomes.

2024年10月9日 · As FREE1 condensates can bind to membranes and modulate MVB biogenesis in the absence of downstream ESCRTs, we speculated that FREE1 membrane wetting and capillarity may underlie ILV invagination...