In this work, we focus on the methods to analyze one sub-type of microautophagy that mediates degradation of cytosolic proteins in late endosome/multi-vesicular bodies (LE/MVB), which is …

2023年12月6日 · In endosomal microautophagy (eMI), 18 the subtype of microautophagy with the highest similarity to CMA, substrates are also targeted for degradation upon recognition of a …

2018年4月13日 · Mammalian eMI originated from studies attempting to characterize the contribution of autophagic pathways to antigen presentation in dendritic cells. Analysis of …

In this work, we show the existence of a compensatory relationship between CMA and eMI and identify a role for the chaperone pro-tein Bag6 in triage and internalization of eMI substrates …

Endosomal microautophagy (eMI) is a type of autophagy that allows for the selective uptake and degradation of cytosolic proteins in late endosome/multi-vesicular bodies (LE/MVB). This …

Chaperone-mediated autophagy (CMA) and endosomal microautophagy (eMI) are pathways for selective degradation of cytosolic proteins in lysosomes and late endosomes, respectively. …

2020年7月9日 · In contrast to CMA, eMI is dependent on MVB formation for uptake of substrates into late endosomes in mammalian cells and in Drosophila [24, 26, 27]. Similar to starvation …

2021年1月1日 · In this work, we focus on the methods to analyze one sub-type of microautophagy that mediates degradation of cytosolic proteins in late endosome/multi-vesicular bodies …

Chaperone-mediated autophagy (CMA) and endosomal microautophagy (eMI) are pathways for selective degradation of cytosolic proteins in lysosomes and late endosomes, respectively.

During endosomal microautophagy (eMI), cytoplasmic proteins are engulfed into late endosomes in an ESCRT machinery-dependent manner. eMI can be KFERQ-specific or occur in bulk and …