
MVH in piRNA processing and gene silencing of retrotransposons
2010年5月1日 · VASA is an evolutionarily conserved RNA helicase essential for germ cell development. The mouse PIWI family proteins MILI and MIWI2 are involved in production of Piwi-interacting RNAs (piRNAs) in fetal male germ cells through a ping-pong amplification cycle.
MVH in piRNA processing and gene silencing of retrotransposons
VASA is an evolutionarily conserved RNA helicase essential for germ cell development. The mouse PIWI family proteins MILI and MIWI2 are involved in production of Piwi-interacting RNAs (piRNAs) in fetal male germ cells through a ping-pong amplification cycle.
Distinct Roles of RNA Helicases MVH and TDRD9 in PIWI
2017年6月19日 · Here we demonstrate that MILI slicing generates a 16-nt by-product that is discarded and a pre-piRNA intermediate that is used for phased piRNA production. The ATPase activity of Mouse Vasa Homolog (MVH) is essential for processing the intermediate into piRNAs, ensuring transposon silencing and male fertility.
VASA is an evolutionarily conserved RNA helicase es-sential for germ cell development. The mouse PIWI family proteins MILI and MIWI2 are involved in pro-duction of Piwi-interacting RNAs (piRNAs) in fetal male germ cells through a ping-pong amplification cycle.
The endonuclease activity of Mili fuels piRNA amplification that ...
2011年10月23日 · Analysis of Mili-bound piRNAs from homozygous MiliDAH fetal gonadocytes revealed a failure of transposon piRNA amplification, resulting in the marked reduction of piRNA bound within Miwi2...
MVH in piRNA processing and gene silencing of retrotransposons
Here, we report that essentially the same abnormalities are observed in MVH (mouse VASA homolog)-deficient mice. Comprehensive analysis of piRNAs in MVH-deficient fetal male germ cells showed that MVH plays crucial roles in the early phase of the ping-pong amplification cycle.
Distinct Roles of RNA Helicases MVH and TDRD9 in PIWI Slicing …
Here we demonstrate that MILI slicing generates a 16-nt by-product that is discarded and a pre-piRNA intermediate that is used for phased piRNA production. The ATPase activity of Mouse Vasa Homolog (MVH) is essential for processing the intermediate into piRNAs, ensuring transposon silencing and male fertility.
Cytoplasmic Compartmentalization of the Fetal piRNA Pathway in …
2009年12月11日 · The germ-cell specific RNA helicase, VASA, is a known component of nuage and pole plasm in Drosophila and has recently been shown to be functional in the piRNA pathway . Mouse VASA homolog (MVH, MGI: DDX4) is required for IMC formation and spermatogenesis ,.
MVH in piRNA processing and gene silencing of …
VASA is an evolutionarily conserved RNA helicase essential for germ cell development. The mouse PIWI family proteins MILI and MIWI2 are involved in production of Piwi-interacting RNAs (piRNAs) in fetal male germ cells through a ping-pong amplification cycle.
Wenda et al. uncover sequential roles for RNA helicases in piRNA biogenesis and function: MVH is essential for maturation of PIWI slicer products to piRNAs, whereas TDRD9 is essential for transposon silencing. Small RNAs called PIWI-interacting RNAs (piRNAs) act as an immune system to suppress transposable elements in the animal gonads.
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