2022年1月11日 · Abnormal WNT signaling increases MYC expression in colon cancer cells in part via oncogenic super-enhancer- (OSE)-mediated gating of the active MYC to the nuclear pore in a poorly understood...

胞浆中稳定积累的β-Catenin进入细胞核后结合LEF/TCF转录因子家族，启动下游靶基因 (如c-myc、Cyclin D1等) 的转录。 Wnt/β-catenin 途径调控着干细胞的多能分化、器官的发育和再生，在功能上与Hippo、Notch和TGF-β等类似，当然也与这些发育调控相关的信号通路有着不同程度的交联。 在这里，主要简单介绍下Wnt与Notch之间的“基情”。 在小肠干细胞和小肠稳态调节过程中，Notch和Wnt信号扮演了重要的调控作用，阻断Notch信号会引起小肠干细胞分化失衡，而 …

C-myc downregulation inhibited P19 cell proliferation caused by activation of Wnt/β-catenin signaling and induced P19 cell differentiation. In conclusion, activation of the Wnt/β-catenin pathway could promote the proliferation and inhibit the differentiation of mouse teratocarcinoma cells by upregulation of c-myc expression.

2022年1月3日 · Wnt signalling plays an important role in the self-renewal of some tissues in mammals. For example, the Wnt signalling pathway is related to the development and renewal of small-intestinal...

2019年11月29日 · WNT signaling activates MYC expression in cancer cells. Here we report that this involves an oncogenic super-enhancer-mediated tethering of active MYC alleles to nuclear pores to increase...

Myc enhances Wnt signaling by enabling the miR-92a/DKK3 axis. Since overexpressed Myc down-regulates DKK3, which acts as a Wnt signaling inhibitor, we hypothesized that in addition to being downstream of Wnt in the signal transduction pathway, Myc could reciprocally enhance Wnt signaling and in doing so boost its own expression.

Deregulated expression of the c-MYC proto-oncogene (MYC) by aberrant Wnt/β-catenin signaling drives colorectal carcinogenesis. In this review, we discuss the current literature pertaining to the identification and characterization of WREs that control oncogenic MYC expression in CRCs.

MYC regulates the levels of numerous WNT-related genes, including the β-catenin co-transcription factor LEF1. MYC activates the transcription of LEF1 and is required for LEF1 expression in colon cancer cells and in primary colonic cells transformed by APC loss of function, a common mutation in colon cancer patients.

Mechanistic evidence indicates that MYC promotes recruitment of RNA methyltransferase (RNMT) to Wnt signaling gene promoters by enhancing phosphorylation of serine 5 on the RNA Polymerase II Carboxy-Terminal Domain, mediated in part through an interaction between the TIP60 acetyltransferase complex and TFIIH.

在这里，我们研究了负责野生型 β-连环蛋白核易位的机制，并解决了 Wnt 通路在 c-Myc/E2F1 肝癌发生中的潜在贡献。方法通过微卫星和蛋白质印迹分析确定Wnt通路成员的状态。结果 无论是否存在 β-连环蛋白突变，大多数 c-Myc/E2F1 HCC 在 Wnt 通路中都表现出多种异常。