2021年6月15日 · Complement receptor 3 (CR3, also known as Mac-1, integrin α M β 2, or CD11b/CD18) is expressed on a subset of myeloid and certain activated lymphoid cells.

2021年6月15日 · Complement receptor 3 (CR3, also known as Mac-1, integrin α M β 2, or CD11b/CD18) is expressed on a subset of myeloid and certain activated lymphoid cells.

Here, we found that SARS-CoV-2 containing a complete Mac1 deletion replicates normally in cell culture but induces an elevated IFN response, has reduced viral loads in vivo, and does not cause significant disease in mice.

2022年4月12日 · Recognition of iC3b by complement receptor type 3 (CR3) fosters pathogen opsonophagocytosis by macrophages and the stimulation of adaptive immunity by complement-opsonized antigens. Here, we...

Mac-1 (alphambeta2) 是一种白细胞粘附受体，在体外已被证明可以与 Fcgamma 受体发生功能性相互作用，以促进免疫复合物 (IC) 刺激的多形核中性粒细胞 (PMN) 功能。 为了研究Mac-1-FcgammaR相互作用在IC介导的体内损伤中的相关性，我们通过静脉注射在野生型和Mac-1缺陷型小鼠中诱导了Fc依赖性抗肾小球基底膜（GBM）肾炎模型注射抗GBM抗体。 Mac-1 无效小鼠和野生型小鼠中最初肾小球 PMN 积累相当，但此后野生型小鼠中增加，突变型小鼠中减少。

2012年10月17日 · 研究发现， 可溶性的 B一 葡 聚糖能够结合并致敏 Mac一 1继而触发吞噬细胞或 NK 细胞对iC3b 调理的肿瘤细胞的细胞毒反应， 这一发现为 B-葡聚 糖在肿瘤免疫治疗中的应用提供了理论基础。 大多数的人类或动物的肿瘤细胞能活化补体并在原位被 iC3b 调理， 肿 瘤细胞表面的iC3b 结合到 8．. 葡聚糖致敏了的Mac一 1后， 吞噬细胞或 NK 细胞就能杀伤肿瘤细胞。

Our results suggested that DAMPs might act on microglial integrin receptor Mac1 to trigger the activation of NADPH oxidase (NOX2). Activated microglial NOX2 increases the production of extracellular reactive oxygen species (ROS), elevating the levels of intracellular ROS of astroglia and sustaining the astroglial C3 expression.

2021年4月29日 · Among the members of this family, complement receptor 3 (CR3; CD11b/CD18, Mac-1, α M β 2) is particularly promiscuous in its functional profile and ligand selectivity.

2019年5月5日 · Cell-surface receptor interactions between leukocyte integrin macrophage-1 antigen (Mac-1, also known as CR3, αMβ2, CD11b/CD18) and platelet glycoprotein Ibα (GPIbα) are critical to vascular inflammation.

2019年5月10日 · Recently, we demonstrated that interleukin-4 (IL-4)-induced fusion of mouse macrophages depends on the integrin macrophage antigen 1 (Mac-1). Surprisingly, the genetic deficiency of intercellular adhesion molecule 1 (ICAM-1), an established ligand of Mac-1, did not impair macrophage fusion, suggesting the involvement of other counter-receptors.