2025年1月15日 · Microangiopathic hemolytic anemia (MAHA) — MAHA is a descriptive term for non-immune hemolysis (ie, Coombs-negative hemolysis) resulting from intravascular red blood cell fragmentation that produces schistocytes on the peripheral blood smear .

Microangiopathic Hemolytic Anemia (MAHA) + low Platelets is TTP until proven otherwise. MAHA is non-immune hemolysis (Coomb's-negative hemolysis) causing RBC fragmentation producing schistocytes; Can occur as a result of Plavix (clopidogrel) use, especially within the first 2 weeks; Pathophysiology

Thrombotic microangiopathy involves tiny clots forming within the microvasculature. This leads to erythrocyte fragmentation (which is termed MAHA: microangiopathic hemolytic anemia). Occlusion of the microvasculature also leads to tissue damage.

ttp主要特征为严重的血小板减少症，maha和(或)不同程度的缺血性器官损伤(特别是脑、心脏和肾脏)。 典型者为临床"五联征"，即MAHA、血小板减少、神经精神异常、发热及肾脏损害 [ 13 , 14 ] 。

TTP Clinical Features. TTP is a diagnosis suspected from clinical features, then later confirmed by laboratory assays. Defined as MAHA with mod-severe thrombocytopenia and associated organ dysfunction. Presenting Clinical Features: Thrombocytopenia (epistaxis, bruising, petechiae etc)

2023年4月26日 · This blog post is going to focus on microangiopathic hemolytic anemias (MAHA) – namely, three major conditions characterized by microangiopathic hemolytic anemia: Thrombotic Thrombocytopenic Purpura (TTP), Hemolytic Uremic Syndrome (HUS), and Disseminated Intravascular Coagulation (DIC).

Thrombotic thrombocytopenic purpura (TTP) is a rare thrombotic microangiopathy characterized by microangiopathic hemolytic anemia, severe thrombocytopenia, and ischemic end organ injury due to microvascular platelet-rich thrombi. TTP results from a ...

微血管病性溶血性贫血 — MAHA为描述性术语，是指血管内红细胞破裂导致的非免疫性溶血(即，Coombs阴性溶血)，外周血涂片可见裂体细胞 。该病常涉及微脉管系统(包括较小的微动脉和毛细血管)异常。

2020年11月3日 · Thrombotic Thrombocytopenic Purpura (TTP) is a rare life-threatening condition that resembles HUS, the distinction is important because TTP can be treated with plasmapheresis. PATHOPHYSIOLOGY. vWF synthesized in endothelial cells and assembled in larger multimers than those seen in plasma (ultra large vWF)

International consensus defines TTP as MAHA with moderate or severe thrombocytopenia, with associated organ dysfunction —this can include neurological, cardiac, gastrointestinal and renal involvement.