
Science:南开大学曹雪涛团队揭示hnRNPA2B1识别病毒DNA并促进IFN …
曹雪涛团队发现hnRNPA2B1(heterogeneous nuclear ribonucleoprotein A2B1, 异质核核糖核蛋白A2B1)是限制DNA病毒感染的IFN-I产生的核起始因子。 在细胞核中直接识别源自病原体的DNA后,hnRNPA2B1转移到细胞质中,从而引发先天性免疫反应。
Cell Metab | 曹雪涛团队揭示腺嘌呤激活细胞核内hnRNPA2B1增强 …
2025年1月14日, 曹雪涛 研究团队在 Cell Metabolism 在线发表了题为 Nuclear adenine activates hnRNPA2B1 to enhance antibacterial innate immunity 的研究论文,报道了细菌感染时细胞核内的腺嘌呤 (Adenine) 含量升高,细胞核内hnRNPA2B1感知并结合Adenine后,hnRNPA2B1向Il1b基因增强子区募集,促进Il1b基因染色质开放与转录,进而促进IL-1β产生并增强抗细菌免疫反 …
核内DNA sensor---hnRNPA2B1 - 知乎 - 知乎专栏
A2B1 is a nuclear-localizing innate sensor ; A2B1 is regulated by JMJD6 via demethylation; Dimerized A2B1 performs nucleocytoplasmic translocation and activates TNK1/IRF3; A2B1 can also directly enhance cGAS-STING cytosolic DNA sensing pathways via regulating m6A of …
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Nuclear adenine activates hnRNPA2B1 to enhance antibacterial …
2025年2月4日 · Here, we report that heterogeneous nuclear ribonucleoprotein A2B1 (hnRNPA2B1) is a sensor for metabolite adenine to launch an antimicrobial innate response through increasing Il1b transcription. Myeloid cell-specific Hnrnpa2b1-cKO mice are more susceptible to bacterial infection, while interleukin 1 beta (IL-1β) supplementation rescues the ...
【前沿进展】Cell Metab | 曹雪涛团队揭示腺嘌呤激活细胞核 …
2025年1月14日,曹雪涛研究团队在Cell Metabolism在线发表了题为 Nuclear adenine activates hnRNPA2B1 to enhance antibacterial innate immunity 的研究论文,报道了细菌感染时细胞核内的腺嘌呤(Adenine)含量升高,细胞核内hnRNPA2B1感知并结合Adenine后,hnRNPA2B1向Il1b基因增强子区募集,促进Il1b基因染色质开放与转录,进而促进IL-1β产生并增强抗细菌免疫反应。 该研究揭示了抗病毒天然免疫受体hnRNPA2B1同时具有重要的抗细菌感染功能,发现 …
Science:曹雪涛团队首次鉴定出病毒DNA引起免疫反应的信号通路 …
该分析揭示了异质核核糖核蛋白a2b1(hnrnpa2b1)作为限制dna病毒感染的i型干扰素产生的核启动子。 在直接识别核病原体衍生的DNA后,hnRNPA2B1易位至细胞质以启动先天免疫应答。
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Emerging roles of hnRNP A2B1 in cancer and inflammation
2022年11月30日 · HnRNP A2B1 was identified as a putative proto-oncogene as overexpression of which in immortalized glioblastoma cells results in malignant transformation, whereas knockdown of hnRNP A2B1 suppresses glioblastoma formation in mice.
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