2022年4月8日 · The makorin RING finger protein (MKRN) gene family encodes proteins (makorins) with a characteristic array of zinc-finger motifs present in a wide array from invertebrates to vertebrates.

Makorin-2 (MKRN2) is a highly conserved protein and yet its functions are largely unknown. We investigated the expression levels of MKRN2 and RAF1 in normal and malignant hematopoietic cells, and leukemia cell lines.

Makorin RING finger protein 3 (MKRN3) is a key inhibitor of the hypothalamic–pituitary–gonadal axis. Loss-of-function mutations in MKRN3 cause familial and sporadic central precocious puberty (CPP), while polymorphisms are associated with age at menarche.

法政大学⇨シマノレーシング⇨リーマン最速を目指すMAKORIN channelです。自転車ネタ特にシクロクロス中心に動画を更新。たまに美容ネタも。

2025年2月19日 · Makorin 1 is a novel SEREX antigen of esophageal squamous cell carcinoma; Data indicate that MKRN1 is a novel modulator of p53 and p21, preferentially leading cells to p53-dependent apoptosis by suppressing p21. MKRN1 may represent a nuclear protein with multiple nuclear functions, including regulating RNA polymerase II-catalyzed transcription.

Makorin ring finger protein 3 is an integral part of covalent linkage of ubiquitin to protein substrates. Similar to others imprinted genes, MKRN3 also evolve under positive selection; however, which codons are specifically selected in MKRN3 during …

2024年12月25日 · MKRN1 (Makorin Ring Finger Protein 1) is a Protein Coding gene. Diseases associated with MKRN1 include West Nile Virus and External Ear Squamous Cell Carcinoma. Among its related pathways are PIP3 activates AKT signaling and Class I MHC mediated antigen processing and presentation.

2023年5月30日 · Makorin RING finger protein 3 (MKRN3) inhibits the secretion of GnRH and plays indispensable roles during the development of pubertal onset, and mutations of MKRN3 showed the commonest genetic cause of central precocious puberty (CPP).

MKRN1 is a modular protein with distinct arrays of C 3 H zinc finger (ZF) motifs, a ZF structure with unusual cysteine/histidine spacing, and a RING domain typically found in E3 ubiquitin ligases (25). Apparently, MKRN1 exhibits divergent functions both in the cell nucleus and the cytoplasm.

Makorin-2 belongs to the makorin RING zinc finger gene family, which encodes putative ribonucleoproteins. Here we cloned the Xenopus makorin-2 (mkrn2) and characterized its function in Xenopus neurogenesis.