2004年6月1日 · Microtubule-associated proteins (MAPs) of the MAP2/Tau family include the vertebrate proteins MAP2, MAP4, and Tau and homologs in other animals. They are best known for their microtubule-stabilizing activity roles regulating microtubule networks but, accumulating evidence suggests a much broader range of functions. regulation of microtubule ...

微管相关蛋白 （Microtubule-associated protein）2 或 MAP2 是一种用作成熟神经元标记物的蛋白质。 基因 MAP2 编码这种蛋白质。 MAP2 属于 MAP2/Tau 家族。 它有四种亚型，即 MAP2a、MAP2b、MAP2c 和 MAP2d。 MAP2 亚型与微管相关并介导它们与肌动蛋白丝的相互作用，从而在组织微管-肌动蛋白网络中发挥关键作用。 此外，MAP2 亚型在神经元和一些神经胶质细胞中受到发育调节和差异表达。 图2.MAP2. MAP2c 在发育中的大脑中表达，其他亚型在成人大脑中 …

Microtubule-associated protein 2 (MAP2) is the predominant cytoskeletal regulator within neuronal dendrites, abundant and specific enough to serve as a robust somatodendritic marker. It influences microtubule dynamics and microtubule/actin interactions to control neurite outgrowth and synaptic functions, similarly to the closely related MAP Tau.

2023年5月31日 · A superfamily of microtubule-associated proteins, MAP2, MAP4, and tau, promote the polymerization of microtubules, stabilize the formed microtubules, and affect the physical properties of ...

2023年4月5日 · 1、 神经元树突标志物：微管相关蛋白Microtubule-associated protein-2 (MAP-2)：Neuron Dendrite-specific MAP; protein found specifically in dendritic branching of neuron 是组成神经元细胞骨架的重要组成成…

All MAP2 isoforms bind to microtubules. Neurons were grown in tissue culture and stained with antibody to MAP2 protein in green and MAP tau in red using the immunofluorescence technique. MAP2 is found only in dendrites and perikarya, while tau is found not only in the dendrites and perikarya but also in axons.

2023年7月1日 · MAP2 monomers specifically bind to the end of tau fibrils, preventing recruitment of further tau and MAP2 monomers onto the fibril tip. The findings uncover a new function for MAP2 as a tau fibril cap that could play a significant role in modulating tau propagation in disease and may hold promise as a potential intrinsic protein inhibitor.

1991年5月1日 · Tau and MAP2 are two of the major microtubule-associated proteins in the vertebrate nervous system. They promote microtubule assembly and stability, and might be involved in the establishment and maintenance of neuronal polarity.

2022年8月22日 · Microtubule-associated proteins tau and MAP2 cooperatively form protein envelopes that compact the underlying tubulin lattice, revealing a novel role for these proteins in altering microtubule...

2004年12月23日 · Microtubule-associated proteins (MAPs) of the MAP2/Tau family include the vertebrate proteins MAP2, MAP4, and Tau and homologs in other animals. All three vertebrate members of the family have alternative splice forms; all isoforms share a conserved carboxy-terminal domain containing microtubule-binding repeats, and an amino-terminal projection ...