MAP2K4 encodes a dual-specificity kinase that belongs to the Ser/Thr protein kinase family. MAP2K4 phosphorylates MAP kinases in response to various environmental stresses or …

2024年12月25日 · MAP2K4 (Mitogen-Activated Protein Kinase Kinase 4) is a Protein Coding gene. Diseases associated with MAP2K4 include Colorectal Cancer and Breast Cancer. …

MAP2K4 is targeted by genetic inactivation in ovarian cancer and restricted to high grade serous and endometrioid carcinomas in our cohort. These results indicated that MKK4 acts as a tumor …

2018年5月24日 · Our findings suggest that cancers having mutations in MAP3K1 or MAP2K4, which are frequent in tumors of breast, prostate and colon, may respond to MEK inhibitors. …

2024年6月18日 · As selective MAP2K4 inhibitors have recently been developed, this provides a potentially novel combination treatment strategy for KRAS-mutant cancers 17,18. Therefore, …

该基因编码丝裂原活化蛋白激酶 (MAPK) 家族的成员。 该家族的成员充当多种生化信号的整合点，并参与多种细胞过程，如增殖、分化、转录调控和发育。 它们形成由 MAPKKK、MAPKK …

MAP2K4是一种双特异性激酶，它即可以磷酸化丝氨酸/苏氨酸和酪氨酸残基，也可作为MAPK激酶级联的第二信使。 MAP2K4蛋白包括激酶结构域 (KD)（102-367），C-和N terminal结构域。 …

MAP2K4 encodes a dual-specificity kinase (mitogen-activated protein kinase kinase 4, or MKK4) that is mutated in a variety of human malignancies, but the biochemical properties of the …

Mitogen-activated protein kinase kinase 4 (MAP2K4) is a gene that encodes a protein that is a member of the MAP kinase family. The protein functions in the signaling of multiple cellular …

2025年2月8日 · Title: Long noncoding RNA HNF1A-AS1 regulates proliferation and apoptosis of glioma through activation of the JNK signaling pathway via miR-363-3p/MAP2K4. microRNA …