Mitogen-activated protein kinase kinase kinase 3 is an enzyme that in humans is encoded by the MAP3K3 gene, [5] which is located on the long arm of chromosome 17 (17q23.3). [6] This …

2024年12月25日 · MAP3K3 (Mitogen-Activated Protein Kinase Kinase Kinase 3) is a Protein Coding gene. Diseases associated with MAP3K3 include Verrucous Hemangioma and …

该基因产物是一个 626 个氨基酸的多肽，与小鼠 Mekk3 有 96.5% 的同一性。 它的催化结构域与其他几种激酶密切相关，包括小鼠 Mekk2、烟草 NPK 和酵母 Ste11。 Northern 印迹分析揭示了 …

Mitogen Activated Protein (MAP) kinase kinase kinase (MAPKKK, [1] MKKK, [2] M3K, [3] or, MAP3K[4]) is a serine/threonine-specific protein kinase which acts upon MAP kinase kinase. …

2023年6月7日 · Efficient regulation of type I interferon and NF-κB signaling by members of the mitogen-activated protein (MAP) kinase kinase kinase (MAP3K) family plays an important role …

MAP3K3 overexpression is an independent poor prognostic indicator in ovarian carcinoma. MAP3K3 may potentially not only serve as diagnostic/prognostic markers for patients with lung …

2024年12月27日 · MAP3K3，也称为MAPKKK3，是一个关键的信号传导分子，属于丝裂原活化蛋白激酶激酶激酶（MAP3K）家族。 这个基因的表达模式在不同的组织和发育阶段中表现出显 …

2025年2月8日 · Mitogen activated protein kinase kinase kinase 3 (MAP3K3/MEKK3) overexpression is an early event in esophageal tumorigenesis and is a predictor of poor …

宣武医院张鸿祺教授团队在《brain》揭示map3k3或pik3ca体细胞突变是散发脑脊髓海绵状血管畸形的核心遗传机制。 研究阐述了致病机制、出血风险等，改变传统认识，为疾病认识、分子 …

Mitogen Activated Protein Kinase Kinase Kinase 3 (MAP3K3) is a crucial component involved in the activation of NF-κB in response to lipopolysaccharide stimulation. It undergoes …

Predicted to enable protein serine/threonine kinase activity. Acts upstream of or within blood vessel development and positive regulation of p38MAPK cascade. Predicted to be active in …

Enables MAP kinase activity; MAP kinase kinase activity; and phosphotyrosine residue binding activity. Involved in several processes, including negative regulation of Apolipoprotein binding …

2015年6月19日 · MAP3K3 is involved in both the immune response and in tumor progression. Its potential biological role in vitro in lung cancer cell lines and the association of mRNA/protein …

Efficient regulation of type I interferon and NF-κB signaling by members of the mitogen-activated protein (MAP) kinase kinase kinase (MAP3K) family plays an important role in antiviral …

2014年1月2日 · MEKK3 is also called MAP3K3, a kinase capable of activating both the ERK and the stress-activated protein kinase cascades. It is positioned upstream of SEK and MEK in the …

Here we analysed whole-exome sequencing data for patients with CCM and found that ∼40% of them have a single, specific MAP3K3 mutation [c.1323C>G (p.Ile441Met)] but not any other …

2015年6月19日 · MAP3K3 is involved in both the immune response and in tumor progression. Its potential biological role in vitro in lung cancer cell lines and the association of mRNA/protein …

MAPK1/3 kinase-dependent ULK1 degradation attenuates mitophagy and promotes breast cancer bone metastasis. The ERK phosphorylation levels in the amygdala predict anxiety symptoms …

MAP3K3 is involved in both the immune response and in tumor progression. Its potential biological role in vitro in lung cancer cell lines and the association of mRNA/protein expression …

Pharos is the web interface for data collected by the Illuminating the Druggable Genome initiative. Target, disease and ligand information are collected and displayed.