Maspin (mammary serine protease inhibitor) is a protein that in humans is encoded by the SERPINB5 gene. [5] This protein belongs to the serpin ( ser ine p rotease in hibitor) superfamily. [ 5 ] SERPINB5 was originally reported to function as a tumor suppressor gene in epithelial cells, suppressing the ability of cancer cells to invade and ...

maspin与serpin超家族的Ser蛋白激酶抑制物有重要同源性，与卵清蛋白也有31%的同源性。 maspin在乳腺上皮细胞中广泛表达，但在恶性肿瘤细胞及浸润性癌中表达降低，转移灶中不表达。

Maspin (mammary serine protease inhibitor) was identified in 1994 by subtractive hybridization analysis of normal mammary tissue and breast cancer cell lines. Subsequently, emerging evidence portrays maspin as a multifaceted protein, interacting ...

2012年7月1日 · In this review, we outline the regulation and roles of Maspin in normal and developmental biology while discussing novel evidence and emerging theories related to its functions in cancer. We provide insight into the immense therapeutic potential of Maspin and the challenges related to its successful clinical translation.

In this report we demonstrate that maspin is an effective inhibitor of angiogenesis. In vitro, it acted directly on cultured endothelial cells to stop their migration towards basic fibroblast...

Maspin is a 42-kDa protein that belongs to the serpin superfamily of Ser ine P roteinase In hibitors. This implies that it shares conformational features that are present in all of the crystal structures of other serpins and serpin:protease complexes that have been reported to date.

2019年12月18日 · Maspin is a member of the clade B serine protease inhibitor superfamily and exhibits diverse regulatory effects in various types of solid tumors. We compared the expressions of maspin and determined its potential biological functions and regulatory mechanisms in bladder carcinoma cells in vitro and …

2021年5月31日 · Mammary serine protease inhibitor (maspin) is a tumor suppressor gene that is downregulated during carcinogenesis and breast cancer progression.

Maspin, a non-inhibitory member of the serine protease inhibitor superfamily, has been characterized as a tumor suppressor gene in multiple cancer types. Among the established anti-tumor effects of Maspin are the inhibition of cancer cell invasion, attachment to extracellular matrices, increased sen …

Maspin基因是一种肿瘤抑制基因,编码一种丝氨酸蛋白酶抑制剂。 近年来的研究表明,Maspin基因在抑制细胞的运动、增殖和肿瘤新生血管生成等方面起到重要作用,进而抑制肿瘤的发生和发展。