MAX (also known as myc-associated factor X) is a gene that in humans encodes the MAX transcription factor. [5][6] The protein product of MAX contains the basic helix-loop-helix and leucine zipper motifs. It is therefore included in the bHLHZ family of transcription factors.

2024年12月25日 · MAX (MYC Associated Factor X) is a Protein Coding gene. Diseases associated with MAX include Pheochromocytoma and Polydactyly-Macrocephaly Syndrome. Among its related pathways are Gene expression (Transcription) and Regulation of activated PAK-2p34 by proteasome mediated degradation.

2012年7月1日 · MYC-associated protein X (MAX) is a ubiquitous, constitutively expressed protein that plays a central role in controlling the MYC/MAX/MAX dimerization protein 1 (MXD1) axis, one of the better-known cellular networks whose deregulation contributes to the genesis of many human cancers.

If you have a mutation in the MAX gene, this means you have a condition called hereditary paraganglioma-pheochromocytoma (PGL/PCC) syndrome. MAX mutations increase your risk for certain types of tumors, including:

2020年5月28日 · Our genomic occupancy and gene expression studies reveal that MAX and MNT repress multiple genes, including those involved in the 1C pathway, which may contribute to the tumor-suppressive function of MAX.

2012年5月14日 · Recently we identified germline mutations in a new tumor suppressor susceptibility gene, MAX (MYC-associated factor X), which predisposes carriers to PCC. How MAX mutations contribute to PCC/PGL and associated phenotypes remain unclear.

2021年3月25日 · Germline MAX mutations are associated with PCs, ganglioneuromas, neuroblastomas, pituitary neuroendocrine tumors, and, possibly, parathyroid adenomas, as well as nonendocrine tumors of chondrosarcoma and lung adenocarcinoma, suggesting MAX is a novel multiple endocrine neoplasia gene.

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Context: MYC-associated factor X (MAX) has been recently described as a new susceptibility pheochromocytoma (PHEO) gene with a total of ~40 reported cases. At present, no study has specifically described the functional imaging phenotype of MAX-related PHEO.

HGNC Approved Gene Symbol: MAX. Cytogenetic location: 14q23.3 Genomic coordinates (GRCh38) : 14:65,006,101-65,102,695 (from NCBI)