IL-25 and IL-33 are the predominant ILC2-inducing cytokines in this model. The presence of ILC2s in skin, and their production of type 2 cytokines in response to IL-33, identifies a role for ILC2s in the pathogenesis of cutaneous atopic disease.

2017年2月22日 · The epithelial- and epidermal-derived cytokines IL-25, IL-33, and thymic stromal lymphopoietin (TSLP) are upregulated during innate immune responses to allergen in asthma and AD and prime type 2...

MC903即 卡泊三醇，是一种维生素D3的低钙类似物，广泛用于治疗银屑病。 研究发现，局部使用MC903可激发小鼠上皮角质细胞高表达TSLP，促进CD4+T细胞向Th2细胞分化及激活并释放炎症细胞因子，引起小鼠产生特应性皮炎表型。 数据展示. 图2.使用克立硼罗软膏可明显降低MC903诱导的AD模型组小鼠皮肤厚度及疾病评分，以及细胞因子的水平。 恶唑酮（Oxazolone,OXA）与1,2,4-二硝基氟苯（1,2,4-Dinitrofluorobenzene, DNFB）等化合物属于半抗原，能与皮肤组织蛋 …

2024年2月29日 · In this study, we investigated the protective effect of DMOG on MC903 (calcipotriol)-induced type 2 skin inflammation. Morphological and immunological changes were assessed by H-E staining, flow cytometry and RT-qPCR. DMOG treatment attenuated MC903-induced skin inflammation in a T cell-independent manner.

Roles of IL-25, IL-33, and TSLP in skin swelling and inflammation and ILC2 infiltration in BALB/c mice strains. MC903 or vehicle was applied topically for 4 d to the ear of wild-type or knockout mice as indicated.

2024年10月14日 · 卡泊三醇（MC903），是一种维生素D3类似物，广泛用于治疗银屑病。 过去研究发现，局部使用MC903可激发小鼠上皮角质细胞高表达TSLP，促进CD4+T细胞向Th2细胞分化及激活并释放炎症细胞因子，引起小鼠产生特应性皮炎表型。 A-B.治疗期间耳厚变化。 C.小鼠血清总IgE水平。 数据表示为平均值±SEM。 (A-B. 双因素方差分析; C. 单因素方差分析; ** p< 0.01)。 银屑病（Psoriasis），是以表皮角质细胞增生为特征的皮肤病。 其临床特征表现为皮 …

2025年3月19日 · This study investigates the potential of ultraviolet (UV)-treated riboflavin in AD treatment. Using a MC903-induced mouse model, we demonstrate that topical UV-treated riboflavin significantly attenuates AD progression. ... Interleukin-25 (IL-25), IL-33, and IL-1β mRNA levels were less pronounced. Notably, non-UV-treated riboflavin showed no ...

为探讨ILC2在AD中的作用，我们使用卡泊三醇（MC903）诱导的AD样小鼠模型，采用流式细胞仪检测皮损中ILC2的比例，并通过抗体拮抗ILC2初步阐明ILC2在MC903诱导的AD样小鼠2型炎症反应中发挥作用。

2017年1月7日 · Topical application of vitamin D3 or of its low-calcemic analog MC903 induces changes in skin morphology and inflammation resembling immune perturbations observed in acute lesions of patients with AD. Mice treated with MC903 or vitamin D3 additionally display increased serum IgE levels, as observed in patients with extrinsic AD.

2013年1月30日 · AD in humans is linked to cytokines interleukin-33 (IL-33), IL-25, and thymic stromal lymphopoietin (TSLP) in the skin. To this end, the authors investigated in mice whether the ILC2s played a role in inflammation at the skin barrier and if …