The MCF7 line retains several characteristics of differentiated mammary epithelium including ability to process estradiol via cytoplasmic estrogen receptors and the capability of forming domes. The cells express the WNT7B oncogene.

MCF-7 is the acronym of Michigan Cancer Foundation-7, referring to the institute in Detroit where the cell line was established in 1973 by Herbert Soule and co-workers. [2] . The Michigan Cancer Foundation is now known as the Barbara Ann Karmanos Cancer Institute. [3]

2015年3月31日 · MCF-7 is the most studied human breast cancer cell line in the world, and results from this cell line have had a fundamental impact upon breast cancer research and patient outcomes. But of the authors for the nearly 25000 scientific publications that used this cell line, how many know the unique story of its isolation and development?

When grown in 3D using scaffold-free agarose hydrogels, MCF-7 human breast cancer cells self-organize to form directionally-oriented microtissues that contain a luminal space, reminiscent of the in vivo structure of the mammary gland.

The current paper provides a broad description of the MCF-7 cell line, including the molecular profile, proliferation, migration, invasion, spheroid formation, its involvement in angiogenesis and lymphangiogenesis and its interaction with the mesenchymal stem cells.

Researchers utilize MCF-7 cells to explore the intricate dance of hormones like estrogen and tamoxifen in regulating the proliferation of cancer cells, delving into the molecular intricacies from spheroid formation to clinical breast cancer progression.

Among many cell lines, the MCF-7 line has been widely used in in vitro breast cancer research worldwide for many years. It is positive for estrogen (ER), progesterone (PR), human epidermal growth (HER2), EGFR, and E-cadherin.

MCF-7 is a commonly used breast cancer cell line, that has been propagated for many years by multiple groups (7). It proves to be a suitable model cell line for breast cancer investigations worldwide, including those regarding anticancer drugs (8).

2012年4月26日 · MCF-7 is a human breast cancer cell line with estrogen, progesterone and glucocorticoid receptors [26]. It is derived from the pleural effusion of a 69-year-old Caucasian metastatic breast cancer (adenocarcinoma) in 1970 by Dr Soule of the Michigan Cancer Foundation, Detroit, MI [27].

2015年3月31日 · MCF-7 is the most studied human breast cancer cell line in the world, and results from this cell line have had a fundamental impact upon breast cancer research and patient outcomes. But of the authors for the nearly 25000 scientific publications that used this cell line, how many know the unique story of its isolation and development?