The McLafferty rearrangement is a reaction observed in mass spectrometry during the fragmentation or dissociation of organic molecules.

When hydrogen is available at the gamma position on carbonyl compounds, these compounds undergo a specific rearrangement due to the cleavage of multiple bonds, including the bonds at alpha and gamma positions. This reaction is known as the McLafferty rearrangement.

2022年2月28日 · The McLafferty rearrangement is a characteristic fragmentation of the molecular ion of a carbonyl compound containing at least one gamma hydrogen.

2023年1月26日 · What is McLafferty rearrangement? McLafferty rearrangement was first described by Fred McLafferty in 1956 and it is one of the most predictable fragmentation patterns for the ionized organic molecule in mass spectrometry.

McLafferty rearrangement is the initial step in the formation of the m/z 71 ion with the involvement of the H-atom from position 6, which is in the proper distance from the carbonylic oxygen only in the endo-isomer.

C 2 H 4 O + m/z 44 is produced by the McLafferty rearrangement of an aldehyde and is a characteristic peak that is very useful for interpretation of aldehydes. The McLafferty compliment, C 5 H 10 + , is observed at 70 m/z .

2023年2月11日 · The McLafferty rearrangement is a common cleavage that occurs in carbonyl compounds that have a hydrogen three atoms away from carbonyl group. This rearragnement yields a carbonyl-containing radical cation via β-cleavage …