2019年1月24日 · Low and high scale mapping of the glial activation on brain sections of mice subjected to 30 minutes middle cerebral artery occlusion (MCAO) was correlated with that of the neuronal cell death,...

2022年2月9日 · This study aims to determine the roles of cranial bone transport (CBT), a novel, effective, and simple surgical technique, in the recovery of ischemic stroke using middle cerebral artery occlusion (MCAO) rat model.

2016年2月13日 · Our results suggested that macrophage depletion is a potential intervention that can promote tissue repair and remodeling after brain ischemia, reduce demyelination and microglia activation, and enhance focal microvessel density. Ischemic stroke is the second leading cause of death and the most common cause of disability worldwide [1, 2].

2023年5月30日 · Here, we review the middle cerebral artery occlusion (MCAo) techniques that are widely used in stroke research in rodents. We also highlight newly emerging approaches for in vivo imaging and staining that have the potential to provide more nuanced insights into the pathophysiology of stroke, as well as serve as indices for testing the effects ...

Many focal cerebral ischemia models utilize the middle cerebral artery occlusion (MCAO) evoked by coagulation to induce ischemic damage in the cortex and mimic the pathology observed in human patients.

2021年5月26日 · Brain injury was induced by middle cerebral artery occlusion (MCAO) in adult rats and pretreated with eriodictyol (low dose: 20 mg/kg; medium dose: 40 mg/kg; high dose: 80 mg/kg) or saline.

2022年9月2日 · Experimental cerebral ischemia was induced by middle cerebral artery occlusion (MCAO) in adult male C57BL/6 mice and simulated by oxygen–glucose deprivation in N2a-BV2 cells in co-cultivation. Lomitapide significantly increased the survival rate, reduced the neuronal tissue loss, and improved the neurological function after MCAO.

2022年9月2日 · Methods: Experimental cerebral ischemia was induced by middle cerebral artery occlusion (MCAO) in adult male C57BL/6 mice and simulated by oxygen-glucose deprivation in N2a-BV2 cells in co-cultivation. Results: Lomitapide significantly increased the survival rate, reduced the neuronal tissue loss, and improved the neurological function after MCAO.

In a 1-h tMCAO mice model and in the peripheral blood of ischemic patients, the CNCs levels were significantly higher, specifically the NeuN + /CD45 − /DAPI + cells. 66 Overall, these were...

2022年9月8日 · A middle cerebral artery occlusion/reperfusion (MCAO/R) model in adult male Sprague–Dawley rats was established in vivo, and cultured neurons were exposed to oxygen–glucose deprivation/reoxygenation (OGD/R) to simulate I/R injury in vitro.