VEGF mRNA is upregulated as early as 3 h after the onset of MCAO, reaches peak level around 24 h, and remains increased for up to 7 days after MCAO in rats . Also, VEGF protein is found to be increased in neurons, astrocytes, and macrophages, and its receptor, Flt-1, is also increased in endothelial cells over days to weeks following MCAO in ...

2021年7月1日 · To determine if aflibercept could attenuate the stroke-induced increase in VEGF signaling in obese mice, we administered either IgG (control) or 10 mg/kg of aflibercept at 3 hours posttransient MCAO. Analysis of VEGF-A and VEGFR2 gene expression levels at 3 days poststroke showed a significant reduction in the ipsilateral hemispheres of ...

Effects of intraventricular VEGF treatment on infarct size and cell damage after MCAO. Rats underwent MCAO and were treated with intraventricular aCSF (MCAO) or VEGF (MCAO + VEGF), and infarct size was measured on cresyl violet–stained brain sections (a).

2015年11月5日 · In our study, RT-PCR and western blot revealed that HIF-1α was up-regulated by MCAO. Galangin down-regulated HIF-1α, VEGF, Frizzled-1 and LRP6, reduced the phosphorylation of β-catenin and ...

In a rat model of transient focal ischemia induced by middle cerebral artery occlusion (MCAO), VEGF (1–3 days after ischemia) exerts multiple effects, such as neuroprotection, neurogenesis in the dentate gyrus and the subventricular zone, and …

2012年5月1日 · Focal cerebral ischemia/reperfusion was induced by the middle cerebral artery occlusion (MCAO) method. In a dose response experiment, low (1.25 ng/μL), middle (2.5 ng/μL) and high (5.0 ng/μL) doses of VEGF were administered 2 h …

VEGF expression is initially detectable 6 hours after MCAO in the pia overlying the infarct region ( arrows in B ), and in scattered glia-like cells in the infarct region of the cortex ...

Vascular endothelial growth factor (VEGF) is an endothelial cell specific mitogen that has been implicated in hypoxia-mediated angiogenesis under physiological and pathological conditions. We used the middle cerebral artery occlusion model (MCAO) in the rat to investigate VEGF mRNA and protein local …

2017年10月20日 · 探讨电针（EA）在甘树（BL 18）和神舒（BL 23）对脑梗死灶周围血管内皮生长因子（VEGF）和血小板内皮细胞粘附分子-1（PECAM-1）/ CD31的影响在大脑中动脉阻塞（MCAO）大鼠中的作用及其可能的机制，从而为针灸治疗脑缺血性中风提供了新的策略。 将180只健康的雄性Sprague-Dawley（SD）雄性大鼠随机分为假手术组，模型组，穴位组和非穴位组，每组45只。 除假手术组外，所有大鼠均采用改良线栓法建立MCAO模型。 穴位组大鼠在甘 …

In this study, we attempted to determine an additional mechanism of treadmill exercise-mediated motor and cognitive functional recovery through the caveolin-1/VEGF pathway associated with BDNF in the ischemic penumbra of MCAO mice.