MCM2-7 is required for both DNA replication initiation and elongation; its regulation at each stage is a central feature of eukaryotic DNA replication. [3] During G1 phase, the two head-to-head Mcm2-7 rings serve as the scaffold for the assembly of the bidirectional replication initiation complexes at the replication origin.

2022年4月19日 · mcm基因家族包括mcm2~7六个成员，广泛存在于包括从酵母到人类等真核生物中，具有调控细胞分裂的作用。 MCM名称来源为minichromosome mantenance，即微小染色体维持基因。

2021年6月25日 · Inhibition of MCM2-7 by treatment with ciprofloxacin inhibits NEPC cell proliferation and migration in vitro, significantly delays NEPC tumor xenograft growth, and partially reverses the...

2023年1月15日 · 这项新研究的结果提供了人类起始前复合物---mcm2-7复合物---的高分辨率结构和机理信息，将来可用于开发靶向mcm2-7复合物的无毒抗癌药物。

2018年7月24日 · A heterohexameric complex composed of minichromosome maintenance protein 2–7 (MCM2–7), which acts as a key replicative enzyme in eukaryotes, is crucial for initiating DNA synthesis only once per cell cycle. The MCM complex remains inactive through the G1 phase, until the S phase, when it is activated to initiate replication.

2025年1月2日 · In eukaryotes, the ring-shaped hetero-hexameric protein, MCM2-7, represents the core of the replicative helicase. MCM2-7 loading, also known as pre-replicative complex (pre-RC) formation, is a...

2024年8月24日 · Origin recognition complex (ORC)-dependent loading of the replicative helicase MCM2-7 onto replication origins in G1-phase forms the basis of replication fork establishment in S-phase. However,...

2024年3月6日 · The MCM2-7 complex is a hexameric protein complex that serves as a DNA helicase. It unwinds the DNA double helix during DNA replication, thereby providing the single-stranded replication template. In recent years, it has become clear that the MCM2-7 complex has additional functions that extend well beyond its role in DNA replication.

2023年6月28日 · The mini-chromosome maintenance proteins 2-7 (MCM2-7) hexamer is a protein complex that is key for eukaryotic DNA replication, which occurs only once per cell cycle. To achieve DNA replication, eukaryotic cells developed multiple mechanisms that control the timing of the loading of the hexamer onto …

2024年6月24日 · The MCM2-7 helicase plays a crucial role in unwinding the double-stranded DNA template during DNA replication. Recent studies indicate that the MCM2-7 helicase subunit Mcm2 also facilitates the transfer of the parental histone H3-H4 tetramer (parH3:H4tet) onto the newly replicated lagging strand.