Sep 28, 2022 · G6PD overexpression in Drosophila Melanogaster and mice protects against metabolic stress, oxidative damage, and age-associated functional decline, and results in an extended median lifespan. This review discusses whether the well-known positive effects of exercise training in skeletal muscle are mediated through an increase in G6PD. 1.

Nov 22, 2024 · These evaluations help to visualize the possible conformational changes associated with C385 point mutations. We aimed to perform conventional MDS simulations to evaluate potential changes in ligand-binding affinity for structural and catalytic NADP + and the glucose-6-phosphate (G6P) substrate.

Aug 11, 2023 · Glucose-6-phosphate dehydrogenase (G6PD) deficiency is an erythro-enzymopathy that has been recognized as the most common cause—through an X-linked hereditary genetic defect due to mutations in the G6PD gene—of CNSHA, which affects nearly 500 million people worldwide. G6PD deficiency leads to a defect in the PPP in red blood cells [5].

Glucose 6-phosphate (G6P) accumulates in endoplasmic reticulum (ER) and cytosol in GSD1a and GSD1b, respectively. G6P availability directly modulates long-term complications in patients.

Abstract: Glucose 6-phosphate dehydrogenase (G6PDH) fulfills an essential role in cell physiology by catalyzing the production of NADPH+and of a precursor for the de novo synthesis of ribose 5-phosphate.

Feb 17, 2025 · Glucose-6-phosphate dehydrogenase (G6PD) is a housekeep-ing protein with 514 amino acids that is also the rate-limiting enzyme of PPP, catalyzing G6P into6-phosphogluconolactone (6PGL) and producing the f i rst NADPH of this pathway.

Glucose-6-phosphate dehydrogenase (G6PD) is a key regulatory enzyme in the pentose phosphate pathway which produces nicotinamide adenine dinucleotide phosphate (NADPH) to maintain an adequate reducing environment in the cells and is especially ...

It is important to understand the molecular basis of G6PD deficiency to understand how gene mutations can impact structure, stability, and enzymatic function. In this work, we reviewed and compared the functional and structural data generated through the characterization of 20 G6PD variants using different approaches.

The generation of reducing equivalent NADPH via glucose-6-phosphate dehydrogenase (G6PD) is critical for the maintenance of redox homeostasis and reductive biosynthesis in cells. NADPH also plays key roles in cellular processes mediated by redox ...

Jan 23, 2025 · Here, we present two cryo-EM structures of the 40-kDa human G6Pase: a wild-type apo form and a mutant G6Pase-H176A with G6P bound, elucidating the structural basis for substrate recognition and hydrolysis. G6Pase comprises nine transmembrane helices and possesses a large catalytic pocket facing the lumen.